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Bupivacaine Hydrochloride structure, CAS 73360-54-0

Bupivacaine Hydrochloride

CAS Number73360-54-0

SynonymsWin 11,318; Bupivacaine HCl H2-O; 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide hydrate hydrochloride; Bupivacaine hydrochloride; Marcaine (TN); 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide,hydrate,hydrochloride; 2-Piperidinecarboxamide,1-butyl-N-(2,6-dimethylphenyl)-,monohydrochloride,monohydrate

Molecular FormulaC18H31ClN2O2

Molecular Weight342.90

Purity98%%

Density

Boiling Point

Melting Point255-259℃

Flash Point

Appearance

EINECS

MSDSChineseEnglish

Symbol6.1

Signal WordWarning

Cat. No.: 2A-1173477 Purity: 98%%
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Quality Control of [ 73360-54-0 ] Purity: 98%% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number73360-54-0
Catalog No.2A-1173477
Chinese Name盐酸布比卡因
SynonymsWin 11,318; Bupivacaine HCl H2-O; 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide hydrate hydrochloride; Bupivacaine hydrochloride; Marcaine (TN); 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide,hydrate,hydrochloride; 2-Piperidinecarboxamide,1-butyl-N-(2,6-dimethylphenyl)-,monohydrochloride,monohydrate
Molecular FormulaC18H31ClN2O2
Molecular Weight342.90
Purity98%
Melting Point255-259℃
ApplicationBupivacaine hydrochloride monohydrate is an NMDA receptor inhibitor. Bupivacaine hydrochloride monohydrate blocks sodium, L-calcium and potassium channels. Bupivacaine hydrochloride monohydrate effect
PubChem ID7848513
MDL NumberMFCD00941462
SMILES[Cl-].[N+H]1(C(CCCC1)C(=O)Nc2c(cccc2C)C)CCCC.O
InChI1S/C18H28N2O.ClH.H2O/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3;;/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21);1H;1H2
InChI KeyHUCIWBPMHXGLFM-UHFFFAOYSA-N
NACRES CodeNA.24
UNSPSC41116107
Hazard Symbols6.1
MSDSmsds/173780_1_73360_54_0.pdf
BioactivityBupivacaine hydrochloride monohydrate is a NMDA receptor inhibitor. Bupivacaine hydrochloride monohydrate can block sodium, L-calcium, and potassium channels. Bupivacaine hydrochloride monohydrate potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine hydrochloride monohydrate can be used for the research of chronic pain[1][2][3]. Related Catalog Signaling Pathways >> Neuronal Signaling >> iGluR Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cancer Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Target NMDA Receptor References [1]. Meaghan A Paganelli, et al. Actions of Bupivacaine, a widely used local anesthetic, on NMDA receptor responses. J Neurosci. 2015 Jan 14;35(2):831-42. [2]. Alexander P Schwoerer, et al. A Comparative Analysis of Bupivacaine and Ropivacaine Effects on Human Cardiac SCN5A Channels. Anesth Analg. 2015 Jun;120(6):1226-34. [3]. Carsten Stoetzer, et al. Inhibition of Voltage-Gated Na+ Channels by Bupivacaine Is Enhanced by the Adjuvants Buprenorphine, Ketamine, and Clonidine. Reg Anesth Pain Med.Jul/Aug 2017;42(4):462-468. Chemical & Physical Properties Melting Point 255-259℃ Molecular Formula C18H31ClN2O2 Molecular Weight 342.90 Exact Mass 342.20700 PSA 45.06000 LogP 5.22160 InChIKey HUCIWBPMHXGLFM-UHFFFAOYSA-N SMILES CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C.Cl.O
Use ofBupivacaine hydrochloride monohydrate is a NMDA receptor inhibitor. Bupivacaine hydrochloride monohydrate can block sodium, L-calcium, and potassium channels. Bupivacaine hydrochloride monohydrate potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine hydrochloride monohydrate can be used for the research of chronic pain[1][2][3]. Properties Articles58 Name bupivacaine hydrochloride hydrate Synonym More Synonyms Bupivacaine Hydrochloride Biological Activity Description Bupivacaine hydrochloride monohydrate is a NMDA receptor inhibitor. Bupivacaine hydrochloride monohydrate can block sodium, L-calcium, and potassium channels. Bupivacaine hydrochloride monohydrate potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine hydrochloride monohydrate can be used for the research of chronic pain[1][2][3]. Related Catalog Signaling Pathways >> Neuronal Signaling >> iGluR Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cancer Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR NMDA Receptor References [1]. Meaghan A Paganelli, et al. Actions of Bupivacaine, a widely used local anesthetic, on NMDA receptor responses. J Neurosci. 2015 Jan 14;35(2):831-42. [2]. Alexander P Schwoerer, et al. A Comparative Analysis of Bupivacaine and Ropivacaine Effects on Human Cardiac SCN5A Channels. Anesth Analg. 2015 Jun;120(6):1226-34. [3]. Carsten Stoetzer, et al. Inhibition of Voltage-Gated Na+ Channels by Bupivacaine Is Enhanced by the Adjuvants Buprenorphine, Ketamine, and Clonidine. Reg Anesth Pain Med.Jul/Aug 2017;42(4):462-468. Chemical & Physical Properties Exact Mass 342.20700 PSA 45.06000 LogP 5.22160 InChIKey HUCIWBPMHXGLFM-UHFFFAOYSA-N
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Bupivacaine hydrochloride) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (Bupivacaine hydrochloride) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Bupivacaine hydrochloride) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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