CAS Number1867-73-8
SynonymsN-Methyladenosine; 6-methylaminopurine riboside; N(6)-methyladenosine; Adenosine,N-methyl; 6-N-Methyladenoside; n6-methyladenosine; 6-Methylaminopurine D-riboside; 6-METHYLAMINOPURINE 9-RIBOFURANOSIDE; 6-Methylaminopurine ribonucleoside; 6-Methylaminopurinosine
Molecular FormulaC11H15O4N5
Molecular Weight281.27
Density1.85g/cm3
Boiling Point649.1ºC at 760mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1867-73-8 |
| Catalog No. | 2A-1172962 |
| Chinese Name | N6-甲基腺苷 |
| Synonyms | N-Methyladenosine; 6-methylaminopurine riboside; N(6)-methyladenosine; Adenosine,N-methyl; 6-N-Methyladenoside; n6-methyladenosine; 6-Methylaminopurine D-riboside; 6-METHYLAMINOPURINE 9-RIBOFURANOSIDE; 6-Methylaminopurine ribonucleoside; 6-Methylaminopurinosine |
| Molecular Formula | C11H15O4N5 |
| Molecular Weight | 281.27 |
| Density | 1.85g/cm3 |
| Boiling Point | 649.1ºC at 760mmHg |
| Storage Condition | 2-8°C |
| Application | N6-Methyladenosine is the most prevalent internal (non-cap) modification of messenger RNA (mRNA) present in all higher eukaryotes. |
| HTC | 2934999090 |
| PubChem ID | 610343 |
| MDL Number | MFCD00005739 |
| SMILES | CNc1ncnc2c1ncn2C1OC(CO)C(O)C1O |
| InChI | InChI=1S/C11H15N5O4/c1-12-9-6-10(14-3-13-9)16(4-15-6)11-8(19)7(18)5(2-17)20-11/h3-5,7-8,11,17-19H,2H2,1H3,(H,12,13,14) |
| InChI Key | VQAYFKKCNSOZKM-IOSLPCCCSA-N |
| MSDS | msds/173250_1_1867_73_8.pdf |
| Use of | N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. Properties Name N6-methyladenosine Synonym More Synonyms N6-Methyladenosine Biological Activity Description N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. Related Catalog Signaling Pathways >> Others >> Others Natural Products >> Alkaloid Research Areas >> Others In Vitro N6-methyladenosine (m6A) is selectively recognized by the human YTH domain family 2 (YTHDF2) protein to regulate mRNA degradation. N6-methyladenosine (m6A), a prevalent internal modification in the messenger RNA of all eukaryotes, is post-transcriptionally installed by m6A methyltransferase (e.g., MT-A70) within the consensus sequence of G(m6A)C (70%) or A(m6A)C (30%). N6-methyladenosine (m6A)-containing RNAs are greatly enriched in the YTHDF-bound portion and diminished in the flow-through portion[1]. N6-methyladenosine (m6A), the most abundant internal RNA modification, functions in diverse biological processes, including regulation of embryonic stem cell self-renewal and differentiation. N6-methyladenosine (m6A) is a large protein complex, consisting in part of methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) catalytic subunits[2]. References [1]. Wang X, et al. N6-methyladenosine-dependent regulation of messenger RNA stability. Nature. 2014 Jan 2;505(7481):117-20. [2]. Li Y, et al. Genome-wide detection of high abundance N6-methyladenosine sites by microarray. RNA. 2015 Aug;21(8):1511-8. Chemical & Physical Properties Molecular Formula C11H15N5O4 Exact Mass 281.11200 PSA 125.55000 Index of Refraction 1.814 InChIKey VQAYFKKCNSOZKM-IOSLPCCCSA-N Safety Information Hazard Codes Xi HS Code 2934999090 Synthetic Route 6-bromo-9-(2... 74465-47-7 methylamine N6-Methyladenos... Literature: Veliz; Beal Journal of Organic Chemistry, 2001 , vol. 66, # 25 p. 8592 - 8598 6-Chloropurine ... methylamine N6-Methyladenos... Literature: Mikkola, Satu; Koissi, Niangoran; Ketomaeki, Kaisa; Rauvala, Susanna; Neuvonen, Kari; Loennberg, Harri European Journal of Organic Chemistry, 2000 , # 12 p. 2315 - 2323 N6-(N,N'-Di... 17331-15-6 N6-Methyladenos... Literature: Zhang, Jianxing; Chang, Hui-Min; Kane, Robert R. Synlett, 2001 , # 5 p. 643 - 645 Precursor & DownStream Precursor 9 CAS#:74465-47-7 6-bromo-9-(2',3... CAS#:74-89-5 methylamine CAS#:2004-06-0 6-Chloropurine ... CAS#:17331-15-6 N6-(N,N'-Dimeth... DownStream 1 CAS#:443-72-1 N6-Methyladenine |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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