CAS Number13389-03-2
Synonyms2'-Deoxy-8-bromoguanosine; C8-bromo-2'-deoxyguanosine; 8-Br-dG; 8-bromo-2'-deoxyuanosine; 8-Bromo-2'-deoxyguanosine; 8-Bromo-2'-deoxy-D-guanosine; 2-Amino-8-bromo-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one; 8-bromo2'-deoxyguansine
Molecular FormulaC10H12O4N5Br1
Molecular Weight346.14
Density2.5±0.1 g/cm3
Boiling Point727ºC at 760 mmHg
Melting Point>250ºC dec.
AppearancePowder | White to Off-white
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 13389-03-2 |
| Catalog No. | 2A-1172937 |
| Chinese Name | 8-溴2'-脱氧鸟苷 |
| Synonyms | 2'-Deoxy-8-bromoguanosine; C8-bromo-2'-deoxyguanosine; 8-Br-dG; 8-bromo-2'-deoxyuanosine; 8-Bromo-2'-deoxyguanosine; 8-Bromo-2'-deoxy-D-guanosine; 2-Amino-8-bromo-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one; 8-bromo2'-deoxyguansine |
| Molecular Formula | C10H12O4N5Br1 |
| Molecular Weight | 346.14 |
| Density | 2.5±0.1 g/cm3 |
| Boiling Point | 727ºC at 760 mmHg |
| Melting Point | >250ºC dec. |
| Appearance | Powder | White to Off-white |
| Water Solubility | Soluble in dimethyl sulfoxide, warm water and dime |
| Storage Condition | -20°C Freezer |
| Application | 8-Bromo-2'-deoxyguanosine is a purine nucleoside analog. Purine nucleoside analogues have broad antitumor activity and target indolent lymphoid malignancies. The anti-cancer mechanism in this process |
| PubChem ID | 16001546 |
| MDL Number | MFCD01630971 |
| SMILES | NC1=NC(=O)c2nc(Br)n(C3CC(O)C(CO)O3)c2N1 |
| InChI | InChI=1S/C10H12BrN5O4/c11-9-13-6-7(14-10(12)15-8(6)19)16(9)5-1-3(18)4(2-17)20-5/h3-5,17-18H,1-2H2,(H3,12,14,15,19) |
| InChI Key | InChIKey=MKDXZFVCXWXGBQ-UHFFFAOYSA-N |
| MSDS | msds/173224_1_13389_03_2.pdf |
| Bioactivity | 8-Bromo-2'-deoxyguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog References [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. Chemical & Physical Properties Density 2.5±0.1 g/cm3 Boiling Point 727ºC at 760 mmHg Melting Point >250ºC dec. Molecular Formula C10H12BrN5O4 Molecular Weight 346.14 Flash Point 393.5ºC Exact Mass 345.007263 PSA 139.28000 LogP -0.02 Appearance of Characters Powder | White to Off-white Vapour Pressure 3.46E-22mmHg at 25°C Index of Refraction 1.941 Storage condition -20°C Freezer Water Solubility Soluble in dimethyl sulfoxide, warm water and dimethyl formamide. |
| Use of | 8-Bromo-2'-deoxyguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. Properties Name 8-Bromo-2'-deoxyguanosine Synonym More Synonyms 8-Bromo-2'-deoxyguanosine Biological Activity Description 8-Bromo-2'-deoxyguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog References [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. Chemical & Physical Properties Molecular Formula C10H12BrN5O4 Exact Mass 345.007263 PSA 139.28000 LogP -0.02 Appearance of Characters Powder | White to Off-white Index of Refraction 1.941 Water Solubility Soluble in dimethyl sulfoxide, warm water and dimethyl formamide. |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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