| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1213269-23-8 |
| Catalog No. | 2A-1172614 |
| Chinese Name | WZ4002 |
| Synonyms | WZ-4002,WZ4002; WZ4002; S1173_Selleck; WZ-4002 |
| Molecular Formula | C25H27ClN6O3 |
| Molecular Weight | 494.973 |
| Purity | 98% |
| Density | 1.3±0.1 g/cm3 |
| Storage Condition | Room temperature, dry, sealed |
| Application | WZ4002 is a mutation-selective EGFR inhibitor; the IC50 values for EGFRL858R, EGFRL858R/T790M, EGFRE746_A750, and EGFRE746_A750/T790M are 2, 8, 3, and 2 nM respectively. |
| PubChem ID | 87357293 |
| SMILES | C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3OC)ncc2Cl)c1 |
| InChI | InChI=1S/C25H27ClN6O3/c1-4-23(33)28-17-6-5-7-19(14-17)35-24-20(26)16-27-25(30-24)29-21-9-8-18(15-22(21)34-3)32-12-10-31(2)11-13-32/h4-9,14-16H,1,10-13H2,2-3H3,(H,28,33)(H,27,29,30) |
| InChI Key | ITTRLTNMFYIYPA-UHFFFAOYSA-N |
| Transport Info | Product name: WZ4002 |
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