![1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide structure, CAS 301326-22-7](/structures/180000/172266_2_301326_22_7.png)
CAS Number301326-22-7
Synonyms2-Methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide; 1-Methyl-N-{2-methyl-4-[(E)-(2-methylphenyl)diazenyl]phenyl}-1H-pyrazole-5-carboxamide; AhR Antagonist; CH-223191
Molecular FormulaC19H19N5O
Molecular Weight333.387
Purity98.00%
Density1.2±0.1 g/cm3
Boiling Point469.4±45.0 °C at 760 mmHg
Appearanceorange-brown
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 301326-22-7 |
| Catalog No. | 2A-1172044 |
| Chinese Name | 1-甲基-N-[2-METHYL-4-[2-(2-甲苯基)二氮烯基]苯基-1H-吡唑-5-甲酰胺 |
| Synonyms | 2-Methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide; 1-Methyl-N-{2-methyl-4-[(E)-(2-methylphenyl)diazenyl]phenyl}-1H-pyrazole-5-carboxamide; AhR Antagonist; CH-223191 |
| Molecular Formula | C19H19N5O |
| Molecular Weight | 333.387 |
| Purity | 98.00 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 469.4±45.0 °C at 760 mmHg |
| Appearance | orange-brown |
| Water Solubility | DMSO: ≥20mg/mL |
| Storage Condition | Store at +4°C |
| Application | CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist. CH-223191 blocks the binding of TCDD to AhR with an IC50 of 0.03 µM. |
| PubChem ID | 3898178 |
| SMILES | Cc1ccccc1N=Nc1ccc(NC(=O)c2ccnn2C)c(C)c1 |
| InChI | InChI=1S/C19H19N5O/c1-13-6-4-5-7-17(13)23-22-15-8-9-16(14(2)12-15)21-19(25)18-10-11-20-24(18)3/h4-12H,1-3H3,(H,21,25) |
| InChI Key | LKTNEXPODAWWFM-UHFFFAOYSA-N |
| Hazard Symbols | transportation |
| Bioactivity | CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor (AhR). CH-223191 blocks the binding of TCDD to AhR with an IC50 of 0.03 µM. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology References [1]. Zhao B, et al. CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor. Toxicol Sci. 2010 Oct;117(2):393-403. [2]. Kim SH, et al. Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor. Mol Pharmacol. 2006 Jun;69(6):1871-8. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 469.4±45.0 °C at 760 mmHg Molecular Formula C19H19N5O Molecular Weight 333.387 Flash Point 237.7±28.7 °C Exact Mass 333.158966 PSA 75.13000 LogP 3.48 Appearance of Characters orange-brown Vapour Pressure 0.0±1.2 mmHg at 25°C Index of Refraction 1.633 InChIKey LKTNEXPODAWWFM-UHFFFAOYSA-N SMILES Cc1ccccc1N=Nc1ccc(NC(=O)c2ccnn2C)c(C)c1 Storage condition Store at +4°C Water Solubility DMSO: ≥20mg/mL |
| Use of | CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor (AhR). CH-223191 blocks the binding of TCDD to AhR with an IC50 of 0.03 µM. Properties Name 2-methyl-N-[2-methyl-4-[(2-methylphenyl)diazenyl]phenyl]pyrazole-3-carboxamide Synonym More Synonyms CH-223191 Biological Activity Description CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor (AhR). CH-223191 blocks the binding of TCDD to AhR with an IC50 of 0.03 µM. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology References [1]. Zhao B, et al. CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor. Toxicol Sci. 2010 Oct;117(2):393-403. [2]. Kim SH, et al. Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor. Mol Pharmacol. 2006 Jun;69(6):1871-8. Chemical & Physical Properties Molecular Formula C19H19N5O Exact Mass 333.158966 PSA 75.13000 Appearance of Characters orange-brown Index of Refraction 1.633 InChIKey LKTNEXPODAWWFM-UHFFFAOYSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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