CAS Number2107-77-9
Synonyms4-METHYLDAPHNETIN; 7,8-dihydroxy-4-methyl-2H-1-benzopyran-2-one; 7,8-Dihydroxy-4-methyl-2H-chromen-2-one; EINECS 218-290-4; 7,8-dihydroxy-4-methyl-chromen-2-one; 7,8-DIHYDROXY-4-METHYLCOUMARIN; 4-methyl-7,8-dihydroxycoumarin; Coumarin,7,8-dihydroxy-4-methyl; MFCD00016972; 7,8-dihydroxy-4-methyl-2H-2-chromenone; 4-Methyldaphnetine
Molecular FormulaC10H8O4
Molecular Weight192.168
Purity98%%
Density1.5±0.1 g/cm3
Boiling Point421.5±45.0 °C at 760 mmHg
Melting Point242-246 °C(lit.)
AppearanceSolid;White to Light yellow to Light orange powder to crystal
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2107-77-9 |
| Catalog No. | 2A-1172026 |
| Chinese Name | 4-甲基瑞香素 |
| Synonyms | 4-METHYLDAPHNETIN; 7,8-dihydroxy-4-methyl-2H-1-benzopyran-2-one; 7,8-Dihydroxy-4-methyl-2H-chromen-2-one; EINECS 218-290-4; 7,8-dihydroxy-4-methyl-chromen-2-one; 7,8-DIHYDROXY-4-METHYLCOUMARIN; 4-methyl-7,8-dihydroxycoumarin; Coumarin,7,8-dihydroxy-4-methyl; MFCD00016972; 7,8-dihydroxy-4-methyl-2H-2-chromenone; 4-Methyldaphnetine |
| Molecular Formula | C10H8O4 |
| Molecular Weight | 192.168 |
| Purity | 98% |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 421.5±45.0 °C at 760 mmHg |
| Melting Point | 242-246 °C(lit.) |
| Appearance | Solid;White to Light yellow to Light orange powder to crystal |
| Storage Condition | Store in dry conditions of cold -5 degrees, in a v |
| Application | 4-Methyldaphnetin is a precursor for the synthesis of 4-methylcoumarin derivatives. 4-Methyldaphnetin has potent and selective anti-proliferative and apoptosis-inducing effects on several tumor cell l |
| HTC | 2932209090 |
| PubChem ID | 99356 |
| SMILES | Cc1cc(=O)oc2c(O)c(O)ccc12 |
| InChI | InChI=1S/C10H8O4/c1-5-4-8(12)14-10-6(5)2-3-7(11)9(10)13/h2-4,11,13H,1H3 |
| InChI Key | NWQBYMPNIJXFNQ-UHFFFAOYSA-N |
| Hazard Symbols | transportation |
| Bioactivity | 4-Methyldaphnetin is a precursor in the synthesis of derivatives of 4-methyl coumarin. 4-Methyldaphnetin has potent, selective anti-proliferative and apoptosis-inducing effects on several cancer cell lines. 4-Methyldaphnetin possesses radical scavenging property and strongly inhibits membrane lipid peroxidation[1][2][3]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer References [1]. Vázquez R, et al. Pharmacodynamic study of the 7,8-dihydroxy-4-methylcoumarin-induced selective cytotoxicity toward U-937 leukemic cells versus mature monocytes: cytoplasmic p21(Cip1/WAF1) as resistance factor. Biochem Pharmacol. 2013 Jul 15;86(2):210-21. [2]. Jin X, et al. 7,8-Dihydroxy-4-methylcoumarin provides neuroprotection by increasing hippocalcin expression. Neurotox Res. 2015 Apr;27(3):268-74. [3]. Raj HG, et al. Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 5: Pulse radiolysis studies on the antioxidant action of 7,8-diacetoxy-4-methylcoumarin. Bioorg Med Chem. 1999 Sep;7(9):2091-4. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 421.5±45.0 °C at 760 mmHg Melting Point 242-246 °C(lit.) Molecular Formula C10H8O4 Molecular Weight 192.168 Flash Point 176.0±22.2 °C Exact Mass 192.042252 PSA 70.67000 LogP 1.95 Vapour Pressure 0.0±1.0 mmHg at 25°C Index of Refraction 1.652 InChIKey NWQBYMPNIJXFNQ-UHFFFAOYSA-N SMILES Cc1cc(=O)oc2c(O)c(O)ccc12 Storage condition 2-8°C |
| Use of | 4-Methyldaphnetin is a precursor in the synthesis of derivatives of 4-methyl coumarin. 4-Methyldaphnetin has potent, selective anti-proliferative and apoptosis-inducing effects on several cancer cell lines. 4-Methyldaphnetin possesses radical scavenging property and strongly inhibits membrane lipid peroxidation[1][2][3]. Properties Name 7,8-dihydroxy-4-methylchromen-2-one Synonym More Synonyms 4-Methyldaphnetin Biological Activity Description 4-Methyldaphnetin is a precursor in the synthesis of derivatives of 4-methyl coumarin. 4-Methyldaphnetin has potent, selective anti-proliferative and apoptosis-inducing effects on several cancer cell lines. 4-Methyldaphnetin possesses radical scavenging property and strongly inhibits membrane lipid peroxidation[1][2][3]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer References [2]. Jin X, et al. 7,8-Dihydroxy-4-methylcoumarin provides neuroprotection by increasing hippocalcin expression. Neurotox Res. 2015 Apr;27(3):268-74. [3]. Raj HG, et al. Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 5: Pulse radiolysis studies on the antioxidant action of 7,8-diacetoxy-4-methylcoumarin. Bioorg Med Chem. 1999 Sep;7(9):2091-4. Chemical & Physical Properties Molecular Formula C10H8O4 Exact Mass 192.042252 PSA 70.67000 Index of Refraction 1.652 InChIKey NWQBYMPNIJXFNQ-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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