| Chemical & Physical Properties | |
|---|---|
| CAS Number | 448906-42-1 |
| Catalog No. | 2A-1171301 |
| Chinese Name | 2-(1H-吲哚-3-基羰基)-4-噻唑羧酸甲酯 |
| Synonyms | ite |
| Molecular Formula | C14H10N2O3S |
| Molecular Weight | 286.30600 |
| Density | 1.427g/cm3 |
| Boiling Point | 520.4ºC at 760 mmHg |
| Storage Condition | 2-8℃ |
| Application | ITE is a potent endogenous aryl hydrocarbon receptor (AhR) agonist that binds directly to the AHR with a Ki of 3 nM. ITE has immunosuppressive effects. |
| HTC | 2934100090 |
| PubChem ID | 6882073 |
| SMILES | COC(=O)c1csc(C(=O)c2c[nH]c3ccccc23)n1 |
| InChI | InChI=1S/C14H10N2O3S/c1-19-14(18)11-7-20-13(16-11)12(17)9-6-15-10-5-3-2-4-8(9)10/h2-7,15H,1H3 |
| InChI Key | KDDXOGDIPZSCTM-UHFFFAOYSA-N |
| Use of | ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR), binding directly to AHR, with a Ki of 3 nM. ITE also has immunosuppressive activity. Properties Name methyl 2-(1H-indole-3-carbonyl)-1,3-thiazole-4-carboxylate Synonym More Synonyms ITE Biological Activity Description ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR), binding directly to AHR, with a Ki of 3 nM. ITE also has immunosuppressive activity. Related Catalog Signaling Pathways >> Immunology/Inflammation >> Aryl Hydrocarbon Receptor Research Areas >> Inflammation/Immunology Ki: 3 nM (AhR)[1] In Vivo ITE (200 μg, i.p.) significantly suppresses the development of experimental autoimmune uveitis (EAU) in mice. ITE reduces the proportions of cells expressing IFN-γ, IL-17, or IL-10 in mice. ITE also suppresses the secretion of inflammatory cytokines by LN cells in mice[2]. References [1]. Song J, et al. A ligand for the aryl hydrocarbon receptor isolated from lung. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14694-9. [2]. Nugent LF, et al. ITE, a novel endogenous nontoxic aryl hydrocarbon receptor ligand, efficiently suppresses EAU and T-cell-mediated immunity. Invest Ophthalmol Vis Sci. 2013 Nov 13;54(12):7463-9. [3]. Pang LP, et al. ITE inhibits growth of human pulmonary artery endothelial cells. Exp Lung Res. 2017 Oct;43(8):283-292. Chemical & Physical Properties Molecular Formula C14H10N2O3S Exact Mass 286.04100 PSA 100.29000 LogP 2.64200 Index of Refraction 1.688 InChIKey KDDXOGDIPZSCTM-UHFFFAOYSA-N Storage condition 2-8℃ Safety Information Hazard Codes Xi Safety Phrases 26-36 HS Code 2934100090 |
| Tax Rebate | 9.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |
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