| Chemical & Physical Properties | |
|---|---|
| CAS Number | 850140-72-6 |
| Catalog No. | 2A-1171245 |
| Chinese Name | 阿法蒂尼(BIBW2992) |
| Synonyms | Afatinib; Tovok; Tomtovok; BIBW-2992; Gilotrif |
| Molecular Formula | C24H25ClFN5O3 |
| Molecular Weight | 485.938 |
| Purity | 98% |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 676.9±55.0 °C at 760 mmHg |
| Melting Point | 100 - 102 °C |
| Appearance | off-white solid |
| Storage Condition | 0-10°C; avoid heating |
| Application | Afatinib (BIBW 2992) is an irreversible EGFR family inhibitor, inhibiting EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM respectively. |
| PubChem ID | 15180141 |
| SMILES | CN(C)CC=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OC1CCOC1 |
| InChI | InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1 |
| InChI Key | ULXXDDBFHOBEHA-CWDCEQMOSA-N |
| Transport Info | Product name: Afatini (BIBW2992) |
| Related Products in API & Advanced Intermediates | ||
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| Baloxavir marboxil | 1985606-14-1 | 2A-1171161 |
| Saxagliptin hydrate | 945667-22-1 | 2A-1171196 |
| METOPROLOL FUMARATE (200 MG) | 119637-66-0 | 2A-1171199 |
| Cabozantinib | 849217-68-1 | 2A-0171242 |
| THEOPHYLLINE SODIUM GLYCINATE | 2A-1171246 | 2A-1171246 |
| Quetiapine Hydroxy Impurity | 329216-67-3 | 2A-1171258 |
| Sitagliptin Phosphate | 847445-79-8 | 2A-1171280 |
| aztreonam | 149496-40-2 | 2A-1171285 |
| Cabotegravir (GSK744, GSK1265744) | 1051375-10-0 | 2A-1171322 |
| Browse all API & Advanced Intermediates products » | ||
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