
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1092364-38-9 |
| Catalog No. | 2A-1171243 |
| Chinese Name | 波齐奥替尼(HM781-36B) |
| Synonyms | Poziotinib; UNII-OEI6OOU6IK; HM781-36B |
| Molecular Formula | C23H21Cl2FN4O3 |
| Molecular Weight | 491.342 |
| Purity | 98% |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 629.7±55.0 °C at 760 mmHg |
| Appearance | powder |
| Storage Condition | -20℃ |
| Application | Poziotinib (NOV120101; HM781-36B) is an irreversible inhibitor of pan-HER kinase, with IC50 values of 3/5/23nM for HER1/HER2/HER4 respectively. |
| PubChem ID | 56451988 |
| SMILES | C=CC(=O)N1CCC(Oc2cc3c(Nc4ccc(Cl)c(Cl)c4F)ncnc3cc2OC)CC1 |
| InChI | InChI=1S/C23H21Cl2FN4O3/c1-3-20(31)30-8-6-13(7-9-30)33-19-10-14-17(11-18(19)32-2)27-12-28-23(14)29-16-5-4-15(24)21(25)22(16)26/h3-5,10-13H,1,6-9H2,2H3,(H,27,28,29) |
| InChI Key | LPFWVDIFUFFKJU-UHFFFAOYSA-N |
| Transport Info | Product name: Poziotinib (HM781-36B) |
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