Poziotinib (HM781-36B) structure, CAS 1092364-38-9

Poziotinib (HM781-36B)

CAS Number1092364-38-9

SynonymsPoziotinib; UNII-OEI6OOU6IK; HM781-36B

Molecular FormulaC23H21Cl2FN4O3

Molecular Weight491.342

Purity98%%

Density1.4±0.1 g/cm3

Boiling Point629.7±55.0 °C at 760 mmHg

Melting Point

Flash Point

Appearancepowder

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-1171243 Purity: 98%%
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Quality Control of [ 1092364-38-9 ] Purity: 98%% SDS Specification MoL

Chemical & Physical Properties
CAS Number1092364-38-9
Catalog No.2A-1171243
Chinese Name波齐奥替尼(HM781-36B)
SynonymsPoziotinib; UNII-OEI6OOU6IK; HM781-36B
Molecular FormulaC23H21Cl2FN4O3
Molecular Weight491.342
Purity98%
Density1.4±0.1 g/cm3
Boiling Point629.7±55.0 °C at 760 mmHg
Appearancepowder
Storage Condition-20℃
ApplicationPoziotinib (NOV120101; HM781-36B) is an irreversible inhibitor of pan-HER kinase, with IC50 values ​​of 3/5/23nM for HER1/HER2/HER4 respectively.
PubChem ID56451988
SMILESC=CC(=O)N1CCC(Oc2cc3c(Nc4ccc(Cl)c(Cl)c4F)ncnc3cc2OC)CC1
InChIInChI=1S/C23H21Cl2FN4O3/c1-3-20(31)30-8-6-13(7-9-30)33-19-10-14-17(11-18(19)32-2)27-12-28-23(14)29-16-5-4-15(24)21(25)22(16)26/h3-5,10-13H,1,6-9H2,2H3,(H,27,28,29)
InChI KeyLPFWVDIFUFFKJU-UHFFFAOYSA-N
Transport InfoProduct name: Poziotinib (HM781-36B)
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