| Chemical & Physical Properties | |
|---|---|
| CAS Number | 548-54-9 |
| Catalog No. | 2A-1171226 |
| Chinese Name | 紫色杆菌素 |
| Synonyms | (3Z)-3-[5-(5-hydroxy-1H-indol-3-yl)-2-oxo-1H-pyrrol-3-ylidene]-1H-indol-2-one |
| Molecular Formula | C20H13N3O3 |
| Molecular Weight | 343.34 |
| Purity | 98.00 |
| Density | 1.549g/cm3 |
| Boiling Point | 821.4ºC at 760mmHg |
| Application | Violadin is a secondary metabolite produced by a variety of microorganisms and has powerful anti-cancer effects and low side effects. Violadin has antioxidant properties. Apoptosis inducers[1][2]. |
| HTC | 2933990090 |
| PubChem ID | 14900447 |
| SMILES | O=C1N=c2ccccc2=C1c1cc(-c2c[nH]c3ccc(O)cc23)[nH]c1O |
| InChI | InChI=1S/C20H13N3O3/c24-10-5-6-15-12(7-10)14(9-21-15)17-8-13(19(25)23-17)18-11-3-1-2-4-16(11)22-20(18)26/h1-9,21,24H,(H,22,26)(H,23,25)/b18-13- |
| InChI Key | SHLJIZCPRXXHHZ-UHFFFAOYSA-N |
| Hazard Symbols | transportation |
| Bioactivity | Violacein, a secondary metabolite produced by several microorganisms, possesses potent anticancer and low side effects. Violacein possesses antioxidant properties. Apoptosis inducer[1][2]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Target Microbial Metabolite In Vitro Violacein (0.25-3 µM; 24h; HCT116 and HT29 cells) possesses anticancer activity in both 2D and 3D cell models[1]. Violacein decreases RTKs expression and disturbs signaling pathways in CRC cells[1]. Cell Viability Assay[1]. Cell Line: HCT116 and HT29 (1.8 × 104 cells/well-100 µL) cells. Concentration: 0.25, 0.5, 1.0, 1.5, 2.0, 2.5, and 3.0 µM. Incubation Time: 24h. Result: In the 2D culture model, the violacein treatment reduced the cell viability, since there was a decrease in formazan production in the HT29 and HCT116 cell lines. Moreover, HT29 was more sensitive to violacein, as evidenced by the IC50 value (0.6 μM) compared to HCT116 (1.2 μM). References [1]. Patricia F de Souza Oliveira, et al. Violacein negatively modulates the colorectal cancer survival and epithelial-mesenchymal transition. J Cell Biochem. 2022 Jul;123(7):1247-1258. [2]. Marlon Konzen, et al. Antioxidant properties of violacein: possible relation on its biological function. Bioorg Med Chem. 2006 Dec 15;14(24):8307-13. Chemical & Physical Properties Density 1.549g/cm3 Boiling Point 821.4ºC at 760mmHg Molecular Formula C20H13N3O3 Molecular Weight 343.34 Flash Point 450.6ºC Exact Mass 343.09600 PSA 101.20000 LogP 3.11110 Index of Refraction 1.804 InChIKey SHLJIZCPRXXHHZ-UHFFFAOYSA-N SMILES O=C1N=c2ccccc2=C1c1cc(-c2c[nH]c3ccc(O)cc23)[nH]c1O |
| Use of | Violacein, a secondary metabolite produced by several microorganisms, possesses potent anticancer and low side effects. Violacein possesses antioxidant properties. Apoptosis inducer[1][2]. Properties Articles29 Name Violacein Synonym More Synonyms Violacein Biological Activity Description Violacein, a secondary metabolite produced by several microorganisms, possesses potent anticancer and low side effects. Violacein possesses antioxidant properties. Apoptosis inducer[1][2]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Microbial Metabolite References [1]. Patricia F de Souza Oliveira, et al. Violacein negatively modulates the colorectal cancer survival and epithelial-mesenchymal transition. J Cell Biochem. 2022 Jul;123(7):1247-1258. [2]. Marlon Konzen, et al. Antioxidant properties of violacein: possible relation on its biological function. Bioorg Med Chem. 2006 Dec 15;14(24):8307-13. Chemical & Physical Properties Molecular Formula C20H13N3O3 Exact Mass 343.09600 PSA 101.20000 LogP 3.11110 Index of Refraction 1.804 InChIKey SHLJIZCPRXXHHZ-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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