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TAFENOQUINE SUCCINATE structure, CAS 106635-81-8

TAFENOQUINE SUCCINATE

CAS Number106635-81-8

SynonymsTafenoquine succinate; UNII-DL5J0B8VSS; Tafenoquine Succinate; tafenoquine maleate; Etaquine; Tafenoquine (Succinate)

Molecular FormulaC28H34F3N3O7

Molecular Weight581.58100

Purity98%%

Density1.237g/cm3

Boiling Point565.6ºC at 760mmHg

Melting Point

Flash Point

Appearance

EINECS

MSDSChineseEnglish

Symboltransportation

Signal WordWarning

Cat. No.: 2A-1171016 Purity: 98%%
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Quality Control of [ 106635-81-8 ] Purity: 98%% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number106635-81-8
Catalog No.2A-1171016
Chinese NameTafenoquine Succinate
SynonymsTafenoquine succinate; UNII-DL5J0B8VSS; Tafenoquine Succinate; tafenoquine maleate; Etaquine; Tafenoquine (Succinate)
Molecular FormulaC28H34F3N3O7
Molecular Weight581.58100
Purity98%
Density1.237g/cm3
Boiling Point565.6ºC at 760mmHg
Storage Condition2-8℃
ApplicationTafenoquine Succinate (WR 238605 Succinate) is an 8-aminoquinoline. Tafenoquine as an antimalarial prophylaxis[1].
PubChem ID10255243
SMILESCOc1cc(C)c2c(Oc3cccc(C(F)(F)F)c3)c(OC)cc(NC(C)CCCN)c2n1.O=C(O)CCC(=O)O
InChIInChI=1S/C24H28F3N3O3.C4H6O4/c1-14-11-20(32-4)30-22-18(29-15(2)7-6-10-28)13-19(31-3)23(21(14)22)33-17-9-5-8-16(12-17)24(25,26)27;5-3(6)1-2-4(7)8/h5,8-9,11-13,15,29H,6-7,10,28H2,1-4H3;1-2H2,(H,5,6)(H,7,8)
InChI KeyCQBKFGJRAOXYIP-UHFFFAOYSA-N
Hazard Symbolstransportation
MSDSmsds/171198_2_106635_81_8.pdf
BioactivityTafenoquine Succinate (WR 238605 Succinate) is an 8-aminoquinoline. Tafenoquine is an anti-malarial prophylactic agent[1]. Related Catalog Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection Target Anti-malarial[1] In Vivo Tafenoquine exhibits no anti-malarial activity in CYP 2D knock-out mice when dosed at their ED100 values (3 mg/kg) established in WT mice. Tafenoquine anti-malarial activity is partially restored in humanized/CYP 2D6 knock-in mice when tested at two times its ED100 (6 mg/kg)[1]. References [1]. Marcsisin SR, et al. Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds. Malar J. 2014 Jan 3;13:2. Chemical & Physical Properties Density 1.237g/cm3 Boiling Point 565.6ºC at 760mmHg Molecular Formula C28H34F3N3O7 Molecular Weight 581.58100 Flash Point 295.9ºC Exact Mass 581.23500 PSA 153.23000 LogP 6.61990 InChIKey CQBKFGJRAOXYIP-UHFFFAOYSA-N SMILES COc1cc(C)c2c(Oc3cccc(C(F)(F)F)c3)c(OC)cc(NC(C)CCCN)c2n1.O=C(O)CCC(=O)O Storage condition 2-8℃
Use ofTafenoquine Succinate (WR 238605 Succinate) is an 8-aminoquinoline. Tafenoquine is an anti-malarial prophylactic agent[1]. Properties Articles22 Name butanedioic acid,4-N-[2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl]pentane-1,4-diamine Synonym More Synonyms Tafenoquine (Succinate) Biological Activity Description Tafenoquine Succinate (WR 238605 Succinate) is an 8-aminoquinoline. Tafenoquine is an anti-malarial prophylactic agent[1]. Related Catalog Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection Anti-malarial[1] References [1]. Marcsisin SR, et al. Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds. Malar J. 2014 Jan 3;13:2. Chemical & Physical Properties Molecular Formula C28H34F3N3O7 Exact Mass 581.23500 PSA 153.23000 LogP 6.61990 InChIKey CQBKFGJRAOXYIP-UHFFFAOYSA-N Storage condition 2-8℃
Transport InfoProduct name: Purity: 99.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip.
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