| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1269440-17-6 |
| Catalog No. | 2A-1170999 |
| Chinese Name | Encorafenib |
| Synonyms | LGX-818; Encorafenib; NVP-LGX818-NXA; LGX818; Encorafenib (LGX818) |
| Molecular Formula | C22H27ClFN7O4S |
| Molecular Weight | 540.011 |
| Purity | 98% |
| Density | 1.5±0.1 g/cm3 |
| Appearance | powder |
| Water Solubility | Insuluble (7.0E-4 g/L) (25 ºC) |
| Storage Condition | -20℃ |
| Application | Encorafenib (LGX818) is a highly potent RAF inhibitor with selective anti-proliferative and pro-apoptotic activities on BRAFV600E cells with an EC50 value of 4 nM. |
| PubChem ID | 113916820 |
| SMILES | COC(=O)NC(C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1 |
| InChI | InChI=1S/C22H27ClFN7O4S/c1-12(2)31-11-16(17-6-7-25-21(28-17)26-10-13(3)27-22(32)35-4)20(29-31)15-8-14(23)9-18(19(15)24)30-36(5,33)34/h6-9,11-13,30H,10H2,1-5H3,(H,27,32)(H,25,26,28)/t13-/m0/s1 |
| InChI Key | CMJCXYNUCSMDBY-ZDUSSCGKSA-N |
| Transport Info | Product name: LGX 818 |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| IPI-549 | 1693758-51-8 | 2A-1170991 |
| RO6885247) | 1449598-06-4 | 2A-1170995 |
| Olumacostat Glasaretil | 1261491-89-7 | 2A-1170996 |
| Esaxerenone | 1632006-28-0 | 2A-1170997 |
| L-778123 | 183499-57-2 | 2A-1170998 |
| AZD-5904 | 618913-30-7 | 2A-1171000 |
| BenzeneDiaMidoEthaneThiol N,N'-Bis(2-Mercaptoethyl)isophthalaMide | 351994-94-0 | 2A-1171001 |
| AR-13324 (mesylate) | 1422144-42-0 | 2A-1171002 |
| WWL70 | 947669-91-2 | 2A-1171003 |
| eCF506 | 1914078-41-3 | 2A-1171004 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS