| Chemical & Physical Properties | |
|---|---|
| CAS Number | 942183-80-4 |
| Catalog No. | 2A-1170743 |
| Chinese Name | SCH772984 |
| Synonyms | SCH-772984; SCH772984 |
| Molecular Formula | C33H33N9O2 |
| Molecular Weight | 587.674 |
| Purity | 98.00 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 857.3±65.0 °C at 760 mmHg |
| Appearance | powder |
| Storage Condition | -20℃ |
| Application | SCH772984 effectively inhibits ERK1 and ERK2 activities with IC50 of 4 and 1 nM, respectively. |
| HTC | 2933990090 |
| PubChem ID | 50099060 |
| SMILES | O=C(Nc1ccc2[nH]nc(-c3ccncc3)c2c1)C1CCN(CC(=O)N2CCN(c3ccc(-c4ncccn4)cc3)CC2)C1 |
| InChI | InChI=1S/C33H33N9O2/c43-30(42-18-16-41(17-19-42)27-5-2-24(3-6-27)32-35-11-1-12-36-32)22-40-15-10-25(21-40)33(44)37-26-4-7-29-28(20-26)31(39-38-29)23-8-13-34-14-9-23/h1-9,11-14,20,25H,10,15-19,21-22H2,(H,37,44)(H,38,39)/t25-/m1/s1 |
| InChI Key | HDAJDNHIBCDLQF-RUZDIDTESA-N |
| Use of | SCH772984 potently inhibits ERK1 and ERK2 activity with IC50s of 4 and 1 nM, respectively. Properties Name (3R)-1-[2-oxo-2-[4-(4-pyrimidin-2-ylphenyl)piperazin-1-yl]ethyl]-N-(3-pyridin-4-yl-1H-indazol-5-yl)pyrrolidine-3-carboxamide Synonym More Synonyms SCH772984 Biological Activity Description SCH772984 potently inhibits ERK1 and ERK2 activity with IC50s of 4 and 1 nM, respectively. Related Catalog Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK Research Areas >> Cancer ERK2:1 nM (IC50) ERK1:4 nM (IC50) In Vitro SCH772984 shows EC50 values less than 500 nM in approximately 88% and 49% of BRAF-mutant (n=25) or RAS-mutant (n=35) tumor lines, respectively. Flow cytometric analysis of SCH772984-sensitive melanoma cells revealed a G1 arrest as well as an increase in the sub-G1 fraction indicative of apoptosis. Less than 20% of cells wild-type for both RAS and BRAF (n=61) are sensitive to SCH772984[1]. References [1]. Morris EJ, et al. Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. Cancer Discov. 2013 Jul;3(7):742-50. Chemical & Physical Properties Molecular Formula C33H33N9O2 Exact Mass 587.275696 PSA 126.73000 Index of Refraction 1.694 InChIKey HDAJDNHIBCDLQF-RUZDIDTESA-N Storage condition -20℃ Safety Information HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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