| Chemical & Physical Properties | |
|---|---|
| CAS Number | 186392-40-5 |
| Catalog No. | 2A-1170695 |
| Chinese Name | 5-氯-N-[(1S,2R)-3-(二甲基氨基)-2-羟基-3-氧代-1-(苯基甲基)丙基]-1H-吲哚-2-甲酰胺 |
| Synonyms | UNII-O8EV00W45A; HMS3261K03; cc-263 |
| Molecular Formula | C21H22ClN3O3 |
| Molecular Weight | 399.87100 |
| Purity | 98.00 |
| Melting Point | 190-192°C |
| Appearance | white to off-white |
| Water Solubility | DMSO: >20mg/mL |
| Storage Condition | Refrigerator |
| Application | CP-91149 is an inhibitor of GP (glycogen phosphorylase). CP-91149 promotes the re-synthesis of glycogen but does not cause excessive accumulation of glycogen. CP-91149 has potential for use in type 2 |
| PubChem ID | 14805763 |
| SMILES | CN(C)C(=O)C(O)C(Cc1ccccc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1 |
| InChI | InChI=1S/C21H22ClN3O3/c1-25(2)21(28)19(26)17(10-13-6-4-3-5-7-13)24-20(27)18-12-14-11-15(22)8-9-16(14)23-18/h3-9,11-12,17,19,23,26H,10H2,1-2H3,(H,24,27)/t17-,19+/m0/s1 |
| InChI Key | HINJNZFCMLSBCI-PKOBYXMFSA-N |
| Hazard Symbols | transportation |
| Bioactivity | CP-91149 is a GP (glycogen phosphorylase) inhibitor. CP-91149 promotes glycogen resynthesis, but not its overaccumulation. CP-91149 has the potential for Type II (insulin-dependent) diabetes study[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease In Vitro CP-91149 treatment decreases muscle GP activity by converting the phosphorylated AMP-independent α form into the dephosphorylated AMP-dependent b form and inhibiting GP α activity and AMP-mediated GP b activation[1]. CP-91149 (10, 30, 50 μM) inhibits brain GP and causes glycogen accumulation in A549 cells[2]. Cell Viability Assay[1] Cell Line: Cells were transduced with adenoviruses and incubated in the presence of 25 mM glucose for 2 days. Concentration: 10 µM (glucose− or glucose+ for 18 h). Incubation Time: 3 h. Result: Promoted the conversion of GP a into GP b, according to α model proposed in hepatocytes. Western Blot Analysis[2] Cell Line: A549 cells. Concentration: 0, 10, 30, 50 μM. Incubation Time: 72 h. Result: A significant increase in glycogen accumulation was detected at 10 μM of CP-91149 as compared with untreated cells with a maximal glycogen accumulation at 30 μM. Intracellular glycogen content decreased at 50 μM CP-91149, perhaps explained by additional pharmacological effects of the drug. The dose-dependent accumulation of intracellular glycogen in A549 cells by CP-91149 indicates that CP-91149 inhibits brain GP in tissue culture. Chemical & Physical Properties Melting Point 190-192°C Molecular Formula C21H22ClN3O3 Molecular Weight 399.87100 Exact Mass 399.13500 PSA 88.92000 LogP 3.18630 Appearance of Characters white to off-white InChIKey HINJNZFCMLSBCI-PKOBYXMFSA-N SMILES CN(C)C(=O)C(O)C(Cc1ccccc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1 Storage condition Refrigerator Water Solubility DMSO: >20mg/mL |
| Use of | CP-91149 is a GP (glycogen phosphorylase) inhibitor. CP-91149 promotes glycogen resynthesis, but not its overaccumulation. CP-91149 has the potential for Type II (insulin-dependent) diabetes study[1]. Properties Name 5-chloro-N-[(2S,3R)-4-(dimethylamino)-3-hydroxy-4-oxo-1-phenylbutan-2-yl]-1H-indole-2-carboxamide Synonym More Synonyms CP-91149 Biological Activity Description CP-91149 is a GP (glycogen phosphorylase) inhibitor. CP-91149 promotes glycogen resynthesis, but not its overaccumulation. CP-91149 has the potential for Type II (insulin-dependent) diabetes study[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease Chemical & Physical Properties Exact Mass 399.13500 PSA 88.92000 LogP 3.18630 Appearance of Characters white to off-white InChIKey HINJNZFCMLSBCI-PKOBYXMFSA-N Storage condition Refrigerator |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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