| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2162-31-4 |
| Catalog No. | 2A-1170645 |
| Chinese Name | 2-(四氢-2H-吡喃-2-氧基)乙醇 |
| Synonyms | 2-(Tetrahydro-2H-pyran-2-yloxy)ethanol; 2-(oxan-2-yloxy)ethanol |
| Molecular Formula | C7H14O3 |
| Molecular Weight | 146.184 |
| Purity | 98.00 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 255.3±30.0 °C at 760 mmHg |
| Melting Point | 95ºC 22 mm Hg(lit.) |
| Storage Condition | Room temperature, sealed, dry |
| Application | THP-PEG1-alcohol is a PROTAC linker, belonging to the PEG class. Can be used to synthesize PROTAC molecules. |
| HTC | 2932999099 |
| PubChem ID | 6111054 |
| SMILES | OCCOC1CCCCO1 |
| InChI | InChI=1S/C7H14O3/c8-4-6-10-7-3-1-2-5-9-7/h7-8H,1-6H2 |
| InChI Key | XDBZJXRPEKFIFR-UHFFFAOYSA-N |
| Use of | THP-PEG1-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Properties Name Tetrahydropyranylethyleneglycol Synonym More Synonyms THP-PEG1-alcohol Biological Activity Description THP-PEG1-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 Chemical & Physical Properties Molecular Formula C7H14O3 Exact Mass 146.094299 PSA 38.69000 LogP -0.38 Index of Refraction 1.460 InChIKey XDBZJXRPEKFIFR-UHFFFAOYSA-N Safety Information WGK Germany 3 HS Code 2932999099 Synthetic Route 3,4-Dihydro-2H-pyran CAS#:110-87-2 Ethylene glycol CAS#:107-21-1 THP-PEG1-alcohol CAS#:2162-31-4 Literature: Eshghi, Hossein; Shafieyoon, Parvaneh Phosphorus, Sulfur and Silicon and the Related Elements, 2004 , vol. 179, # 10 p. 2149 - 2152 tert-butyldimet... CAS#:1034098-53-7 THP-PEG1-alcohol CAS#:2162-31-4 Literature: Gopinath, Pushparathinam; Nilaya, Surapaneni; Muraleedharan, Kannoth Manheri Organic Letters, 2011 , vol. 13, # 8 p. 1932 - 1935 3,4-Dihydro-2H-pyran CAS#:110-87-2 Ethylene glycol CAS#:107-21-1 2-[2-(oxan-2-yl... CAS#:71033-27-7 THP-PEG1-alcohol CAS#:2162-31-4 Literature: Synthetic Communications, , vol. 36, # 18 p. 2705 - 2710 Precursor & DownStream Precursor 3 CAS#:110-87-2 3,4-Dihydro-2H-pyran CAS#:107-21-1 Ethylene glycol CAS#:111860-36-7 tetrahydropyran... DownStream 5 CAS#:6581-66-4 tetrahydro-2-me... CAS#:107-21-1 Ethylene glycol CAS#:771-61-9 Pentafluorophenol CAS#:1075204-22-6 2-(tetrahydro-2... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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