| Chemical & Physical Properties | |
|---|---|
| CAS Number | 145918-75-8 |
| Catalog No. | 2A-1170516 |
| Chinese Name | 4-氨基-1-[(2S)-2-(羟甲基)-1,3-二氧杂环戊-4-基]嘧啶-2-酮 |
| Synonyms | S1535_Selleck; Bch-4556; cis-Dioxolane-C; Troxacitabine |
| Molecular Formula | C8H11N3O4 |
| Molecular Weight | 213.19100 |
| Density | 1.71g/cm3 |
| Boiling Point | 422.5ºC at 760mmHg |
| Application | Troxacitabine is a dioxolane analogue with potent antitumor activity. |
| HTC | 2933599090 |
| SMILES | Nc1ccn(C2COC(CO)O2)c(=O)n1 |
| InChI | InChI=1S/C8H11N3O4/c9-5-1-2-11(8(13)10-5)6-4-14-7(3-12)15-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6?,7-/m0/s1 |
| InChI Key | RXRGZNYSEHTMHC-MLWJPKLSSA-N |
| Use of | Troxacitabine is nucleoside analog with potent anticancer activity. Properties Name 4-amino-1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]pyrimidin-2-one Synonym More Synonyms Troxacitabine Biological Activity Description Troxacitabine is nucleoside analog with potent anticancer activity. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cancer In Vitro Troxacitabine has shown cutotoxicity in cancer cell lines of hepatocellular (HepG2), prostate (PC3, DUI45), non-small cell lung (NCI-H460, NCr-322M) colon (HT29), renal (CAK-l, A498, RXF-393, SNI2-C) and pancreatic origin (Pnac-Ol, MiaPa Ca) with IC50s range from 15-35 μM[1][2]. References [1]. Gourdeau H, et al. Antitumor activity of troxacitabine (Troxatyl) against anthracycline-resistant human xenografts. Cancer Chemother Pharmacol. 2002 Dec;50(6):490-6. [2]. Kadhim SA, et al. Potent antitumor activity of a novel nucleoside analogue, BCH-4556 (beta-L-dioxolane-cytidine), in human renal cell carcinoma xenograft tumor models. Cancer Res. 1997 Nov 1;57(21):4803-10. [3]. Weitman S, et al. The new dioxolane, (-)-2'-deoxy-3'-oxacytidine (BCH-4556, troxacitabine), has activity againstpancreatic human tumor xenografts. Clin Cancer Res. 2000 Apr;6(4):1574-8. Chemical & Physical Properties Molecular Formula C8H11N3O4 Exact Mass 213.07500 PSA 99.60000 Index of Refraction 1.694 InChIKey RXRGZNYSEHTMHC-MLWJPKLSSA-N Safety Information HS Code 2933599090 Synthetic Route CAS#:146996-25-0 Troxacitabine CAS#:145918-75-8 Literature: Kim; Schinazi; Shanmuganathan; Jeong; Beach; Nampalli; Cannon; Chu Journal of Medicinal Chemistry, 1993 , vol. 36, # 5 p. 519 - 528 Benzoic acid (2... CAS#:145414-63-7 Troxacitabine CAS#:145918-75-8 Literature: Tetrahedron Letters, , vol. 33, # 46 p. 6899 - 6902 [(2S)-4-(acetyl... CAS#:145875-99-6 Troxacitabine CAS#:145918-75-8 (-)-L-α-dioxola... CAS#:145416-37-1 Literature: Tetrahedron Letters, , vol. 33, # 46 p. 6949 - 6952 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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