CAS Number123-78-4
SynonymsEINECS 204-651-3; (4E)-sphing-4-enine; D-erythro-Sphingosine,synthetical; BRAIN,BOVINE; MFCD00036751; Sphingosine, D-erythro; DErySphingosine; [3H]-Sphingosine; 4-trans-Sphingenine; Sphingosine; 4-Sphingenine; [Fluorescein]-Sphingosine; (2S,3R,4E)-2-Aminooctadec-4-ene-1,3-diol; Sphingenine; EGG SPHINGOSINE; D-erythro-Sphingosine; D-Sphingosine; erythro-4-Sphingenine; CEREBROSIDE; (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol; (-)-D-erythro-Sphingosine; (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-ene-1-ol; BRAIN SPHINGOSINE; (4E)-sphingenine; trans-4-sphingenine; D-erythrosphingosine; C18-Sphingosine; (2S,3R,E)-2-Amino-4-octadecene-1,3-diol; Sphingosine 2S,3R,2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol; UNII:0Y6SVQ612Q
Molecular FormulaC18H37NO2
Molecular Weight299.492
Purity95%
Density0.9±0.1 g/cm3
Boiling Point445.9±45.0 °C at 760 mmHg
Melting Point81-82ºC
AppearanceWhite to off-white crystalline powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 123-78-4 |
| Catalog No. | 2A-1170360 |
| Chinese Name | D-鞘氨醇 |
| Synonyms | EINECS 204-651-3; (4E)-sphing-4-enine; D-erythro-Sphingosine,synthetical; BRAIN,BOVINE; MFCD00036751; Sphingosine, D-erythro; DErySphingosine; [3H]-Sphingosine; 4-trans-Sphingenine; Sphingosine; 4-Sphingenine; [Fluorescein]-Sphingosine; (2S,3R,4E)-2-Aminooctadec-4-ene-1,3-diol; Sphingenine; EGG SPHINGOSINE; D-erythro-Sphingosine; D-Sphingosine; erythro-4-Sphingenine; CEREBROSIDE; (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol; (-)-D-erythro-Sphingosine; (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-ene-1-ol; BRAIN SPHINGOSINE; (4E)-sphingenine; trans-4-sphingenine; D-erythrosphingosine; C18-Sphingosine; (2S,3R,E)-2-Amino-4-octadecene-1,3-diol; Sphingosine 2S,3R,2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol; UNII:0Y6SVQ612Q |
| Molecular Formula | C18H37NO2 |
| Molecular Weight | 299.492 |
| Purity | 95 |
| Density | 0.9±0.1 g/cm3 |
| Boiling Point | 445.9±45.0 °C at 760 mmHg |
| Melting Point | 81-82ºC |
| Appearance | White to off-white crystalline powder |
| Water Solubility | chloroform: 20 mg/mL |
| Storage Condition | Seal and store in a dry place below 0 degrees Cels |
| Application | D-erythro-Sphingosine is a very potent activator of p32 kinase with an EC50 of 8 μM. D-erythro-Sphingosine inhibits protein kinase C (PKC). |
| HTC | 2922199090 |
| PubChem ID | 3613 |
| SMILES | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)CO |
| InChI | InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/b15-14+/t17-,18+/m0/s1 |
| InChI Key | InChIKey=WWUZIQQURGPMPG-KRWOKUGFSA-N |
| Hazard Symbols | transportation |
| Bioactivity | D-erythro-Sphingosine is a very potent activator of p32-kinase with an EC50 of 8 μM. D-erythro-Sphingosine inhibits protein kinase C (PKC). Related Catalog Research Areas >> Cancer Natural Products >> Others Target p32:8 μM (EC50) PKC Human Endogenous Metabolite In Vitro A p32-sphingosine-activated protein kinase responds to low concentrations of D-erythro-Sphingosine with an initial activation observed at 2.5 μM and a peak activity at 10-20 μM. This kinase shows a modest specificity for D-erythro-Sphingosine over other sphingosine tereoisomers, and a preference for sphingosines over ihydrosphingosines[1]. D-erythro-Sphingosine inhibits protein kinase C in vitro[2]. D-erythro-Sphingosine has been shown to inhibit protein kinase C, which affects cell regulation and several signal transduction pathways, and exhibits antitumor promoter activities in various mammalian cells[3]. References [1]. Pushkareva MYu, et al. Regulation of sphingosine-activated protein kinases: selectivity of activation by sphingoid basesand inhibition by non-esterified fatty acids. Biochem J. 1993 Sep 15;294 ( Pt 3):699-703. [2]. Khan WA, et al. Protein kinase C and platelet inhibition by D-erythro-Sphingosine: comparison with N,N-dimethylsphingosine and commercial preparation. Biochem Biophys Res Commun. 1990 Oct 30;172(2):683-91. [3]. Pham VT, et al. A concise synthesis of a promising protein kinase C inhibitor: D-erythro-Sphingosine. Arch Pharm Res. 2007 Jan;30(1):22-7. Chemical & Physical Properties Density 0.9±0.1 g/cm3 Boiling Point 445.9±45.0 °C at 760 mmHg Melting Point 81-82ºC Molecular Formula C18H37NO2 Molecular Weight 299.492 Flash Point 223.5±28.7 °C Exact Mass 299.282440 PSA 66.48000 LogP 6.40 Vapour Pressure 0.0±2.4 mmHg at 25°C Index of Refraction 1.489 Water Solubility chloroform: 20 mg/mL |
| Use of | D-erythro-Sphingosine is a very potent activator of p32-kinase with an EC50 of 8 μM. D-erythro-Sphingosine inhibits protein kinase C (PKC). Properties Articles158 Name sphingosine Synonym More Synonyms D-erythro-Sphingosine Biological Activity Description D-erythro-Sphingosine is a very potent activator of p32-kinase with an EC50 of 8 μM. D-erythro-Sphingosine inhibits protein kinase C (PKC). Related Catalog Research Areas >> Cancer Natural Products >> Others p32:8 μM (EC50) Human Endogenous Metabolite In Vitro A p32-sphingosine-activated protein kinase responds to low concentrations of D-erythro-Sphingosine with an initial activation observed at 2.5 μM and a peak activity at 10-20 μM. This kinase shows a modest specificity for D-erythro-Sphingosine over other sphingosine tereoisomers, and a preference for sphingosines over ihydrosphingosines[1]. D-erythro-Sphingosine inhibits protein kinase C in vitro[2]. D-erythro-Sphingosine has been shown to inhibit protein kinase C, which affects cell regulation and several signal transduction pathways, and exhibits antitumor promoter activities in various mammalian cells[3]. References [1]. Pushkareva MYu, et al. Regulation of sphingosine-activated protein kinases: selectivity of activation by sphingoid basesand inhibition by non-esterified fatty acids. Biochem J. 1993 Sep 15;294 ( Pt 3):699-703. [2]. Khan WA, et al. Protein kinase C and platelet inhibition by D-erythro-Sphingosine: comparison with N,N-dimethylsphingosine and commercial preparation. Biochem Biophys Res Commun. 1990 Oct 30;172(2):683-91. [3]. Pham VT, et al. A concise synthesis of a promising protein kinase C inhibitor: D-erythro-Sphingosine. Arch Pharm Res. 2007 Jan;30(1):22-7. Chemical & Physical Properties Molecular Formula C18H37NO2 Exact Mass 299.282440 PSA 66.48000 Index of Refraction 1.489 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
| Related Products in Active Ingredients | ||
|---|---|---|
| (9-cis,13-cis)-Retinol 15-Acetate; 9,13-Di-cis-retinol 15-Acetate | 29444-27-7 | 2A-9093226 |
| N-(6-[(7-NITRO-2-1,3-BENZOXADIAZOL-4-YL)AMINO]CAPROYL)-PHYTOSPHINGOSINE | 477239-93-3 | 2A-9093397 |
| ASCORBYL GLUCOSIDE | 129499-78-1 | 2A-0201505 |
| BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE | 187393-00-6 | 2A-1166642 |
| ECTOINE | 96702-03-3 | 2A-1169481 |
| C14 CERAMIDE | 34435-05-7 | 2A-0170419 |
| Ascorbyl Tetraisopalmitate | 183476-82-6 | 2A-3174703 |
| Acetyl dipeptide-3 aminohexanoate | 1265905-30-3 | 2A-3175126 |
| Acetyl Hexapeptide- 1 | 448944-47-6 | 2A-3175130 |
| Acetyl Hexapeptide-38 | 1400634-44-7 | 2A-3175131 |
| Browse all Active Ingredients products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS