| Chemical & Physical Properties | |
|---|---|
| CAS Number | 96574-01-5 |
| Catalog No. | 2A-1170356 |
| Chinese Name | 丹酚酸A |
| Synonyms | Target; MMP-9; References |
| Molecular Formula | C26H22O10 |
| Molecular Weight | 494.447 |
| Purity | 98.00 |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 858.7±65.0 °C at 760 mmHg |
| Melting Point | 164-167ºC |
| Appearance | yellow solid |
| Water Solubility | H2O: ≥19mg/mL |
| Storage Condition | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| Application | Salvianolic acid A protects the blood-brain barrier through inhibition of matrix metallotitanase-9 (MMP-9) and anti-inflammatory effects. |
| PubChem ID | 12675 |
| SMILES | O=C(C=Cc1ccc(O)c(O)c1C=Cc1ccc(O)c(O)c1)OC(Cc1ccc(O)c(O)c1)C(=O)O |
| InChI | InChI=1S/C26H22O10/c27-18-7-2-14(11-21(18)30)1-6-17-16(4-9-20(29)25(17)33)5-10-24(32)36-23(26(34)35)13-15-3-8-19(28)22(31)12-15/h1-12,23,27-31,33H,13H2,(H,34,35)/b6-1+,10-5+/t23-/m1/s1 |
| InChI Key | YMGFTDKNIWPMGF-UCPJVGPRSA-N |
| MSDS | msds/170508_2_96574_01_5.pdf |
| Bioactivity | Salvianolic acid A could protect the blood brain barrier through matrix metallopeptidase 9 (MMP-9) inhibition and anti-inflammation. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> MMP Natural Products >> Acids and Aldehydes Research Areas >> Inflammation/Immunology Target MMP-9 In Vivo A significant beneficial effect of Salvianolic acid A (SAA) is observed in the Salvianolic acid A treatment groups. Salvianolic acid A (20 mg/kg) could significantly prolonged the retention time of rats on the plate. While compared with sham operation group, the brain water content in model group significantly increases, which is attenuated significantly by Salvianolic acid A (10 and 20 mg/kg). Compared with the model group, Salvianolic acid A (5, 10, and 20 mg/kg) could maintain the normal structures of neurons and increase neurons number. It is also found that Salvianolic acid A (20 mg/kg) could significantly reduce I/R induced MMP-9 upregulation. While the MMP-2 expression is not significantly affected by Salvianolic acid A. Tissue inhibitors of metalloproteinases (TIMPs) could inhibit the activity of MMPs through high affinity binding to MMPs catalytic domain[1]. References [1]. Zhang W, et al. Salvianolic acid A attenuates ischemia reperfusion induced rat brain damage by protecting the blood brain barrier through MMP-9 inhibition and anti-inflammation. Chin J Nat Med. 2018 Mar;16(3):184-193. Chemical & Physical Properties Density 1.6±0.1 g/cm3 Boiling Point 858.7±65.0 °C at 760 mmHg Melting Point 164-167ºC Molecular Formula C26H22O10 Molecular Weight 494.447 Flash Point 292.9±27.8 °C Exact Mass 494.121307 PSA 184.98000 LogP 4.23 Vapour Pressure 0.0±0.3 mmHg at 25°C Index of Refraction 1.790 InChIKey YMGFTDKNIWPMGF-UCPJVGPRSA-N SMILES O=C(C=Cc1ccc(O)c(O)c1C=Cc1ccc(O)c(O)c1)OC(Cc1ccc(O)c(O)c1)C(=O)O Storage condition Hygroscopic, -20°C Freezer, Under Inert Atmosphere Water Solubility H2O: ≥19mg/mL |
| Use of | Salvianolic acid A could protect the blood brain barrier through matrix metallopeptidase 9 (MMP-9) inhibition and anti-inflammation. Properties Articles32 Name Salvianolic Acid A Synonym More Synonyms Salvianolic acid A Biological Activity Description Salvianolic acid A could protect the blood brain barrier through matrix metallopeptidase 9 (MMP-9) inhibition and anti-inflammation. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> MMP Natural Products >> Acids and Aldehydes Research Areas >> Inflammation/Immunology References [1]. Zhang W, et al. Salvianolic acid A attenuates ischemia reperfusion induced rat brain damage by protecting the blood brain barrier through MMP-9 inhibition and anti-inflammation. Chin J Nat Med. 2018 Mar;16(3):184-193. Chemical & Physical Properties Molecular Formula C26H22O10 Exact Mass 494.121307 PSA 184.98000 Index of Refraction 1.790 InChIKey YMGFTDKNIWPMGF-UCPJVGPRSA-N |
| Transport Info | Product name: Salvianolic acid A |
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