| Chemical & Physical Properties | |
|---|---|
| CAS Number | 944261-79-4 |
| Catalog No. | 2A-1170188 |
| Chinese Name | 5-(4-氯苯基)-N-(3,5-二甲氧基苯基)-2-呋喃甲酰胺 |
| Synonyms | 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furamide; cc-433; A-803467 |
| Molecular Formula | C19H16ClNO4 |
| Molecular Weight | 357.788 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 450.6±45.0 °C at 760 mmHg |
| Melting Point | 128-130?C |
| Appearance | white to tan |
| Water Solubility | DMSO: >10mg/mL |
| Storage Condition | Store at +4°C |
| Application | A 803467 is a Nav1.8 sodium channel blocker with an IC50 of 8 nM and is 100 times more potent than Nav1.2, 1.3, 1.5 and 1.7. |
| HTC | 2932190090 |
| PubChem ID | 24421011 |
| SMILES | COc1cc(NC(=O)c2ccc(-c3ccc(Cl)cc3)o2)cc(OC)c1 |
| InChI | InChI=1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22) |
| InChI Key | VHKBTPQDHDSBSP-UHFFFAOYSA-N |
| Use of | A 803467 is a selective Nav1.8 sodium channel blocker with an IC50 of 8 nM; over 100-fold more selective vs. human Nav1.2, 1.3, 1.5 and 1.7. IC50 value: 8 nMTarget: Nav1.8 sodium channelA 803467 dose-dependently reduces behavioral responses in a variety of neuropathic and inflammatory pain models. Properties Name 5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide Synonym More Synonyms A-803467 Biological Activity Description A 803467 is a selective Nav1.8 sodium channel blocker with an IC50 of 8 nM; over 100-fold more selective vs. human Nav1.2, 1.3, 1.5 and 1.7. IC50 value: 8 nMTarget: Nav1.8 sodium channelA 803467 dose-dependently reduces behavioral responses in a variety of neuropathic and inflammatory pain models. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease References [1]. McGaraughty, et al. A selective NaV1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide)], attenuates spinal neuronal activity in neuropathic rats. Journal of Pharmacology and Experimental Therapeutics (2008), [2]. Jarvis MF, et al. A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. Proc Natl Acad Sci U S A. 2007 May 15;104(20):8520-5. [3]. Joshi SK, et al. Additive antinociceptive effects of the selective Nav1.8 blocker A-803467 and selective TRPV1 antagonists in rat inflammatory and neuropathic pain models. http://www.ncbi.nlm.nih.gov/pubmed/19070548 [4]. Kort ME, et al. Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6812-5. Chemical & Physical Properties Exact Mass 357.076782 PSA 60.70000 Appearance of Characters white to tan Index of Refraction 1.611 InChIKey VHKBTPQDHDSBSP-UHFFFAOYSA-N Safety Information Signal Word Warning Hazard Statements H302 Hazard Codes Xn Risk Phrases R22 RIDADR NONH for all modes of transport HS Code 2932190090 Synthetic Route Total: 1 Page 5-(4-chlorophen... CAS#:57753-80-7 3,5-Dimethoxyaniline CAS#:10272-07-8 CAS#:944261-79-4 Literature: Journal of Medicinal Chemistry, , vol. 51, # 3 p. 407 - 416 Precursor & DownStream Precursor 2 CAS#:57753-80-7 5-(4-chlorophen... CAS#:10272-07-8 3,5-Dimethoxyaniline DownStream 0 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |
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