CAS Number944396-07-0
SynonymsBuparlisib; NVP-BKM120; 5-[2,6-Di(4-morpholinyl)-4-pyrimidinyl]-4-(trifluoromethyl)-2-pyridinamine; 5-(2,6-dimorpholinopyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine; BKM120-NX; BKM120
Molecular FormulaC18H21F3N6O2
Molecular Weight410.393
Density1.4±0.1 g/cm3
Boiling Point645.7±65.0 °C at 760 mmHg
Appearancewhite solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 944396-07-0 |
| Catalog No. | 2A-1170168 |
| Chinese Name | 5-[2,6-二(4-吗啉基)-4-嘧啶基]-4-(三氟甲基)-2-吡啶胺 |
| Synonyms | Buparlisib; NVP-BKM120; 5-[2,6-Di(4-morpholinyl)-4-pyrimidinyl]-4-(trifluoromethyl)-2-pyridinamine; 5-(2,6-dimorpholinopyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine; BKM120-NX; BKM120 |
| Molecular Formula | C18H21F3N6O2 |
| Molecular Weight | 410.393 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 645.7±65.0 °C at 760 mmHg |
| Appearance | white solid |
| Storage Condition | -20℃ |
| Application | NVP-BKM120 is a pan-class I PI3K inhibitor, acting on p110α/p110β/p110δ/p110γ, with IC50 of 52 nM/166 nM/116 nM/262 nM respectively. |
| HTC | 2934999090 |
| PubChem ID | 26514721 |
| SMILES | Nc1cc(C(F)(F)F)c(-c2cc(N3CCOCC3)nc(N3CCOCC3)n2)cn1 |
| InChI | InChI=1S/C18H21F3N6O2/c19-18(20,21)13-9-15(22)23-11-12(13)14-10-16(26-1-5-28-6-2-26)25-17(24-14)27-3-7-29-8-4-27/h9-11H,1-8H2,(H2,22,23) |
| InChI Key | CWHUFRVAEUJCEF-UHFFFAOYSA-N |
| Use of | NVP-BKM120 is a pan-class I PI3K inhibitor, with IC50s of 52, 166, 116 and 262 nM for p110α, p110β, p110δ and p110γ, respectively. Properties Name Buparlisib Synonym More Synonyms BKM120 Biological Activity Description NVP-BKM120 is a pan-class I PI3K inhibitor, with IC50s of 52, 166, 116 and 262 nM for p110α, p110β, p110δ and p110γ, respectively. Related Catalog Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Research Areas >> Cancer p110α:52 nM (IC50) p110α-H1047R:58 nM (IC50) p110α-E545K:99 nM (IC50) p110δ:116 nM (IC50) p110β:166 nM (IC50) p110γ:262 nM (IC50) Vps34:2.4 μM (IC50) mTOR:4.6 μM (IC50) In Vitro NVP-BKM120 (BKM120) exhibits 50-300 nM activity for class I PI3K's, including the most common p110α mutants. Additionally, NVP-BKM120 exhibits lower potency against class III and class IV PI3K's, where 2, 5, >5, and >25 μM biochemical activity is observed for inhibition of VPS34, mTOR, DNAPK, and PI4K, respectively[1]. NVP-BKM120 induces multiple myeloma (MM) cell apoptosis in both dose- and time-dependent manners. NVP-BKM120 at concentrations ≥10 μM induces significant apoptosis in all tested MM cell lines at 24 h (P<0.05, compares with control). Therefore, 10 μM NVP-BKM120 and 24-h treatment are chose in in the following experiments if not stated otherwise. NVP-BKM120 treatment results in a dose-dependent growth inhibition in all tested MM cell lines. NVP-BKM120 IC50 varies among tested MM cells. At 24 h treatment, IC50 for ARP-1, ARK, and MM.1R is between 1 and 10 μM, while IC50 for MM.1S is <1 μM, and IC50 for U266 is between 10 and 100 μM. In summary, NVP-BKM120 treatment results in MM cell growth inhibition and apoptosis in dose- and time-dependent manners[2]. References [1]. Burger MT, et al. Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer. ACS Med Chem Lett. 2011 Aug 26;2(10):774-9. [2]. Zheng Y, et al. Novel phosphatidylinositol 3-kinase inhibitor NVP-BKM120 induces apoptosis in myeloma cells and shows synergistic anti-myeloma activity with dexamethasone. J Mol Med (Berl). 2012 Jun;90(6):695-706. [3]. Ni J, et al. Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases. Nat Med. 2016 Jul;22(7):723-6. [4]. Liu H, et al. Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple Negative Breast Cancer. Cancer Discov. 2018 Mar;8(3):354-369. Chemical & Physical Properties Molecular Formula C18H21F3N6O2 Exact Mass 410.167816 PSA 89.63000 Appearance of Characters white solid Index of Refraction 1.574 InChIKey CWHUFRVAEUJCEF-UHFFFAOYSA-N Storage condition -20℃ Safety Information HS Code 2934999090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| sodium 3-ethoxy-3-oxoprop-1-en-1-olate | 287390-25-4 | 2A-1170158 |
| Gaultheria procumbens extract | 90045-28-6 | 2A-1170162 |
| titanium dihydride | 7704-98-5 | 2A-1170163 |
| 4-Methylsulfonyl-3-(pyrrolidin-1-yl)aniline | 1000018-40-5 | 2A-1170165 |
| P005672 hydrochloride | 1035979-44-2 | 2A-1170166 |
| 3,4-Dichloro-N-(1-Methylbutyl)benza-Mide | 7497-07-6 | 2A-1170169 |
| PST2286 | 26629-41-4 | 2A-1170170 |
| UNC-1215 | 1415800-43-9 | 2A-1170172 |
| Icotinib | 610798-31-7 | 2A-1170173 |
| VU 0357121 | 433967-28-3 | 2A-1170174 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS