CAS Number202825-45-4
SynonymsRALFINAMIDE MESYLATE; (2S)-2-[[[4-[(2-FLUOROPHENYL)METHOXY]PHENYL]METHYL]AMINO]-PROPANAMIDE METHANESULFONATE; Ralfinamide mesylate; (S)-2-((4-((2-Fluorobenzyl)oxy)benzyl)amino)propanamide methanesulfonate
Molecular FormulaC18H23FN2O5S
Molecular Weight398.44900
Purity98.00%
AppearanceWhite to beige powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 202825-45-4 |
| Catalog No. | 2A-1169987 |
| Chinese Name | Ralfinamide mesylate |
| Synonyms | RALFINAMIDE MESYLATE; (2S)-2-[[[4-[(2-FLUOROPHENYL)METHOXY]PHENYL]METHYL]AMINO]-PROPANAMIDE METHANESULFONATE; Ralfinamide mesylate; (S)-2-((4-((2-Fluorobenzyl)oxy)benzyl)amino)propanamide methanesulfonate |
| Molecular Formula | C18H23FN2O5S |
| Molecular Weight | 398.44900 |
| Purity | 98.00 |
| Appearance | White to beige powder |
| Storage Condition | 2-8℃, sealed, dry |
| Application | Ralfinamide mesylate (FCE-26742A mesylate) is an orally available sodium channel blocker derived from α-aminoamide with analgesic properties. |
| HTC | 2924299090 |
| PubChem ID | 46534844 |
| SMILES | CC(NCc1ccc(OCc2ccccc2F)cc1)C(N)=O.CS(=O)(=O)O |
| InChI | InChI=1S/C17H19FN2O2.CH4O3S/c1-12(17(19)21)20-10-13-6-8-15(9-7-13)22-11-14-4-2-3-5-16(14)18;1-5(2,3)4/h2-9,12,20H,10-11H2,1H3,(H2,19,21);1H3,(H,2,3,4)/t12-;/m0./s1 |
| InChI Key | CHQVNINIGBRKGZ-YDALLXLXSA-N |
| Hazard Symbols | transportation |
| Bioactivity | Ralfinamide mesylate (FCE-26742A mesylate) is an orally available Na(+) channel blocker derived from α-aminoamide, with function of suppressing pain[1]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease Target Na(+) channel References [1]. Zhang SH, et al. Ralfinamide administered orally before hindpaw neurectomy or postoperatively provided long-lasting suppression of spontaneous neuropathic pain-related behavior in the rat. Pain. 2008 Oct 15;139(2):293-305. [2]. Liang X, et al. Effects of ralfinamide in models of nerve injury and chemotherapy-induced neuropathic pain. Eur J Pharmacol. 2018 Mar 15;823:27-34. Chemical & Physical Properties Molecular Formula C18H23FN2O5S Molecular Weight 398.44900 Exact Mass 398.13100 PSA 127.10000 LogP 4.04410 InChIKey CHQVNINIGBRKGZ-YDALLXLXSA-N SMILES CC(NCc1ccc(OCc2ccccc2F)cc1)C(N)=O.CS(=O)(=O)O |
| Use of | Ralfinamide mesylate (FCE-26742A mesylate) is an orally available Na(+) channel blocker derived from α-aminoamide, with function of suppressing pain[1]. Properties Name (2S)-2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]propanamide,methanesulfonic acid Synonym More Synonyms Ralfinamide Mesylate Biological Activity Description Ralfinamide mesylate (FCE-26742A mesylate) is an orally available Na(+) channel blocker derived from α-aminoamide, with function of suppressing pain[1]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease Na(+) channel References [1]. Zhang SH, et al. Ralfinamide administered orally before hindpaw neurectomy or postoperatively provided long-lasting suppression of spontaneous neuropathic pain-related behavior in the rat. Pain. 2008 Oct 15;139(2):293-305. [2]. Liang X, et al. Effects of ralfinamide in models of nerve injury and chemotherapy-induced neuropathic pain. Eur J Pharmacol. 2018 Mar 15;823:27-34. Chemical & Physical Properties Molecular Formula C18H23FN2O5S Exact Mass 398.13100 PSA 127.10000 LogP 4.04410 InChIKey CHQVNINIGBRKGZ-YDALLXLXSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. ((2S)-2-[[[4-[(2- fluorophenyl)methoxy]phenyl]methyl]amino]-propanamide methanesulfonate) International Maritime Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. ((2S)-2-[[[4-[(2- fluorophenyl)methoxy]phenyl]methyl]amino]-propanamide methanesulfonate) International air transport hazard regulations: Toxic solid, organic, n.o.s. ((2S)-2-[[[4-[(2-fluorophenyl)methoxy]phenyl]methyl]amino]- propanamide methanesulfonate) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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