CAS Number529-49-7
SynonymsGentisein; 9H-Xanthen-9-one,1,3,7-trihydroxy; 1,3,7-trihydroxy-9H-xanthen-9-one; 1,3,7-trihydroxy-xanthen-9-one; Xanthen-9-one,1,3,7-trihydroxy; 1,3,7-Trihydroxy-xanthen-9-on; XANTHONE DERIV; 1,3,7-trihydroxyxanthone; 1,3,7-trihydroxyxanthen-9-one
Molecular FormulaC13H8O5
Molecular Weight244.20000
Purity95+%
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 529-49-7 |
| Catalog No. | 2A-1169598 |
| Chinese Name | 1,3,7-三羟基-9H-氧杂蒽-9-酮 |
| Synonyms | Gentisein; 9H-Xanthen-9-one,1,3,7-trihydroxy; 1,3,7-trihydroxy-9H-xanthen-9-one; 1,3,7-trihydroxy-xanthen-9-one; Xanthen-9-one,1,3,7-trihydroxy; 1,3,7-Trihydroxy-xanthen-9-on; XANTHONE DERIV; 1,3,7-trihydroxyxanthone; 1,3,7-trihydroxyxanthen-9-one |
| Molecular Formula | C13H8O5 |
| Molecular Weight | 244.20000 |
| Purity | 95+ |
| Application | Gentianin (NSC 329491), the main metabolite of mangiferin, shows the most potent inhibition of serotonin uptake, with an IC50 value of 4.7µM[1][2]. |
| HTC | 2932999099 |
| PubChem ID | 12251 |
| SMILES | O=c1c2cc(O)ccc2oc2cc(O)cc(O)c12 |
| InChI | InChI=1S/C13H8O5/c14-6-1-2-10-8(3-6)13(17)12-9(16)4-7(15)5-11(12)18-10/h1-5,14-16H |
| InChI Key | JJUNZBRHHGLJQW-UHFFFAOYSA-N |
| Use of | Gentisein (NSC 329491), the major metabolite of Mangiferin, shows the most potent serotonin uptake inhibition with an IC50 value of 4.7 µM[1][2]. Properties Name gentisein Synonym More Synonyms Gentisein Biological Activity Description Gentisein (NSC 329491), the major metabolite of Mangiferin, shows the most potent serotonin uptake inhibition with an IC50 value of 4.7 µM[1][2]. Related Catalog Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor References [1]. Wang H, et al. Identification and determination of four metabolites of mangiferin in rat urine. J Pharm Biomed Anal. 2007;45(5):793-798. [2]. Tzankova, Virginia et al. (2010). Inhibition of 5-HT uptake by some constituents of Hypericum annulatum in rat brain in vitro. Pharmacologyonline. 2. Chemical & Physical Properties Molecular Formula C13H8O5 Exact Mass 244.03700 PSA 90.90000 LogP 2.06300 InChIKey JJUNZBRHHGLJQW-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Xanthen-9-one, 1,3,7-trihydroxy- CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA MUTATION DATA TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 10 ug/plate REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 150,141,1985 Safety Information HS Code 2932999099 Synthetic Route Phloroglucinol Gentisic acid Literature: Verbanac, Donatella; Jain, Subhash C.; Jain, Nidhi; Chand, Mahesh; Cipcic Paljetak, Hana; Matijasic, Mario; Peric, Mihaela; Stepanic, Visnja; Saso, Luciano Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 10 p. 3180 - 3185 7-hydroxy-1,3-d... 39838-86-3 Literature: Mondal, Mukulesh; Puranik, Vedavati G.; Argade, Narshinha P. Journal of Organic Chemistry, 2006 , vol. 71, # 13 p. 4992 - 4995 (2,5-dibenzylox... 900501-59-9 Literature: Mondal, Mukulesh; Puranik, Vedavati G.; Argade, Narshinha P. Journal of Organic Chemistry, 2006 , vol. 71, # 13 p. 4992 - 4995 Precursor & DownStream Precursor 8 CAS#:108-73-6 Phloroglucinol CAS#:490-79-9 Gentisic acid CAS#:39838-86-3 7-hydroxy-1,3-d... CAS#:2150-46-1 Methyl2,5-dihyd... DownStream 6 CAS#:529-61-3 Euxanthone CAS#:136083-95-9 (8-acetyloxy-6-... CAS#:13379-35-6 1-HYDROXY-3,7-D... CAS#:3722-54-1 9H-Xanthen-9-on... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| TRANS-2-CHLORO-3 4-DIMETHOXY-B-NITROSTY& | 41122-35-4 | 2A-1169593 |
| 1-(3,4-bis(benzyloxy)phenoxy)-3-(3,4-dimethoxyphenethylamino)propan-2-ol | 782436-39-9 | 2A-1169594 |
| Acetamide, 2,2'-oxybis[N,N-dibutyl- | 82846-38-6 | 2A-1169595 |
| Ro 363 | 74513-77-2 | 2A-1169596 |
| ethyl 3-oxododecanoate | 67342-99-8 | 2A-1169597 |
| Methyl 6-bromo-3-methoxy-2-methylbenzoate | 55289-16-2 | 2A-1169599 |
| 5 6-METHYLENEDIOXY-1-INDANONE 97 | 6412-87-9 | 2A-1169600 |
| hydrazinecarbothioic acid O-methyl ester | 19692-07-0 | 2A-1169601 |
| 1,1,3-trichloronaphthalen-2(1H)-one | 31337-01-6 | 2A-1169603 |
| 3,4-Dichloro-2-naphthol | 57396-89-1 | 2A-1169604 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS