| Chemical & Physical Properties | |
|---|---|
| CAS Number | 556803-08-8 |
| Catalog No. | 2A-1169433 |
| Chinese Name | TCN 213 |
| Molecular Formula | C18H24N4OS2 |
| Molecular Weight | 376.53900 |
| Purity | 98.00 |
| Storage Condition | -20°C, dry, sealed |
| Application | TCN 213 is a selective, surmountable, glycine-dependent GluN1/GluN2A NMDAR antagonist with IC50 of 0.55, 3.5 and 40 μM in the presence of 75, 750 and 7500 nM glycine, respectively. TCN 213 can be used |
| HTC | 2934999090 |
| PubChem ID | 8296526 |
| InChI | InChI=1S/C18H24N4OS2/c23-16(19-11-14-7-3-1-4-8-14)13-24-18-22-21-17(25-18)20-12-15-9-5-2-6-10-15/h2,5-6,9-10,14H,1,3-4,7-8,11-13H2,(H,19,23)(H,20,21) |
| InChI Key | XBAZPYFIYYCZBO-UHFFFAOYSA-N |
| Use of | Properties Name 2-{[5-(Benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl}-N-(cyclohexyl methyl)acetamide TCN 213 Biological Activity Related Catalog Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR In Vitro TCN 213 (30 µM) antagonizes NMDA-evoked currents in neurones transfected with GluN2A subunits[1]. References [1]. McKay, S et al. "Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist." British journal of pharmacology vol. 166,3 (2012): 924-37. Chemical & Physical Properties Molecular Formula C18H24N4OS2 Exact Mass 376.13900 PSA 127.17000 LogP 4.20100 Safety Information Hazard Codes Xi HS Code 2934999090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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