| Chemical & Physical Properties | |
|---|---|
| CAS Number | 34408-14-5 |
| Catalog No. | 2A-1169191 |
| Chinese Name | 8-氯腺嘌呤核苷 |
| Synonyms | 2-chloroadenosine; 8-Chloroadenosine; 8-chloro-adenosine |
| Molecular Formula | C10H12ClN5O4 |
| Molecular Weight | 301.69 |
| Purity | 98.00 |
| Density | 2.2±0.1 g/cm3 |
| Boiling Point | 707.4±70.0 °C at 760 mmHg |
| Storage Condition | Sealed in a cool, dry environment |
| Application | 8-Chloroadenosine (8-Cl-Ado), a unique ribonucleoside analogue, depletes endogenous ATP and subsequently induces phosphorylation and activation of AMPK. 8-Chloroadenosine induces autophagic cell death |
| HTC | 2934999090 |
| PubChem ID | 3718037 |
| SMILES | Nc1ncnc2c1nc(Cl)n2C1OC(CO)C(O)C1O |
| InChI | InChI=1S/C10H12ClN5O4/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,13,14) |
| InChI Key | MHDPPLULTMGBSI-UUOKFMHZSA-N |
| Use of | 8-Chloroadenosine (8-Cl-Ado), a unique ribonucleoside analog, depletes endogenous ATP that subsequently induces the phosphorylation and activation of AMPK. 8-Chloroadenosine induces autophagic cell death. 8-Chloroadenosine effectively inhibited in vivo tumor growth in mice[1]. Properties Name 2-(6-amino-8-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol Synonym More Synonyms 8-Chloroadenosine Biological Activity Description 8-Chloroadenosine (8-Cl-Ado), a unique ribonucleoside analog, depletes endogenous ATP that subsequently induces the phosphorylation and activation of AMPK. 8-Chloroadenosine induces autophagic cell death. 8-Chloroadenosine effectively inhibited in vivo tumor growth in mice[1]. Related Catalog Signaling Pathways >> Epigenetics >> AMPK Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> PI3K/Akt/mTOR >> AMPK References [1]. Christine M Stellrecht, et al. ATP directed agent, 8-chloro-adenosine, induces AMP activated protein kinase activity, leading to autophagic cell death in breast cancer cells. J Hematol Oncol. 2014 Mar 14;7:23. Chemical & Physical Properties Exact Mass 301.057770 PSA 139.54000 LogP -0.46 Index of Refraction 1.912 InChIKey MHDPPLULTMGBSI-UUOKFMHZSA-N Safety Information HS Code 2934999090 Synthetic Route Total: 1 Page N-Benzyladenosine CAS#:4294-16-0 8-Chloroadenosine CAS#:34408-14-5 CAS#:1427459-38-8 CAS#:58-61-7 8-Chloroadenosine CAS#:34408-14-5 Literature: Journal of Organic Chemistry, , vol. 46, # 13 p. 2819 - 2823 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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