CAS Number761437-28-9
Synonyms2-[[5-chloro-2-(2-methoxy-4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]-N-methylbenzamide; 2-[(5-Chloro-2-{[2-methoxy-4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)amino]-N-methylbenzamide; NVP-TAE 226; TAE226
Molecular FormulaC23H25ClN6O3
Molecular Weight468.936
Density1.3±0.1 g/cm3
Appearancelight yellow solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 761437-28-9 |
| Catalog No. | 2A-1169157 |
| Chinese Name | NVP-TAE 226 |
| Synonyms | 2-[[5-chloro-2-(2-methoxy-4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]-N-methylbenzamide; 2-[(5-Chloro-2-{[2-methoxy-4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)amino]-N-methylbenzamide; NVP-TAE 226; TAE226 |
| Molecular Formula | C23H25ClN6O3 |
| Molecular Weight | 468.936 |
| Density | 1.3±0.1 g/cm3 |
| Appearance | light yellow solid |
| Storage Condition | -20℃ |
| Application | NVP-TAE 226 is a dual tyrosine kinase inhibitor targeting FAK and IGF-IR with IC50 of 5.5 nM and 0.14 μM respectively. |
| HTC | 2934999090 |
| PubChem ID | 14907409 |
| SMILES | CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2OC)ncc1Cl |
| InChI | InChI=1S/C23H25ClN6O3/c1-25-22(31)16-5-3-4-6-18(16)27-21-17(24)14-26-23(29-21)28-19-8-7-15(13-20(19)32-2)30-9-11-33-12-10-30/h3-8,13-14H,9-12H2,1-2H3,(H,25,31)(H2,26,27,28,29) |
| InChI Key | UYJNQQDJUOUFQJ-UHFFFAOYSA-N |
| Use of | NVP-TAE 226 is a dual tyrosine kinase inhibitor of FAK (IC50=5.5 nM) and IGF-IR (mean IC50=0.14 μM). Properties Name 2-((5-Chloro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide Synonym More Synonyms TAE226(NVP-TAE226) Biological Activity Description NVP-TAE 226 is a dual tyrosine kinase inhibitor of FAK (IC50=5.5 nM) and IGF-IR (mean IC50=0.14 μM). Related Catalog Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FAK Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Pyk2 Research Areas >> Cancer IC50: 5.5 nM (FAK), 3.5 nM (Pyk2), 0.14 μM (IGF-IR), 0.16 μM (c-Met), 0.36 μM (KDR), 0.48 μM (Flt3)[1] Cell Assay Glioma cell cultures are harvested with 0.05% trypsin and seeded in triplicate at 2×104 in 24-well culture plates for 24 h before drug treatment. Culture medium is used for mock treatment. Cells are harvested at the indicated day after treatment, and viable cells are counted using the Vi-cell viability analyzer. The antiproliferative activity of NVP-TAE 226 (ranging from 0.25 to 1 μM) on cells growing in culture is determined using a tetrazolium-based colorimetric MTT assay[1]. References [1]. Liu TJ, et al. Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo. Mol Cancer Ther, 2007, 6(4), 1357-1367. [2]. Delimont D, et al. Laminin α2-mediated focal adhesion kinase activation triggers Alport glomerular pathogenesis. PLoS One. 2014 Jun 10;9(6):e99083. Chemical & Physical Properties Exact Mass 468.167664 PSA 100.64000 Appearance of Characters light yellow solid Index of Refraction 1.659 InChIKey UYJNQQDJUOUFQJ-UHFFFAOYSA-N Storage condition -20℃ Safety Information HS Code 2934999090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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