CAS Number848695-25-0
Synonyms6-Chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-2-amine; cnf2024; unii-851b9fq7q0; biib021; 6-chloro-9-(4-methoxy-3,5-dimethylpyridin-2-ylmethyl)-9H-purin-2-ylamine
Molecular FormulaC14H15ClN6O
Molecular Weight318.762
Density1.5±0.1 g/cm3
Boiling Point588.5±60.0 °C at 760 mmHg
Melting Point192-193℃
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 848695-25-0 |
| Catalog No. | 2A-1169113 |
| Chinese Name | BIIB 021 |
| Synonyms | 6-Chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-2-amine; cnf2024; unii-851b9fq7q0; biib021; 6-chloro-9-(4-methoxy-3,5-dimethylpyridin-2-ylmethyl)-9H-purin-2-ylamine |
| Molecular Formula | C14H15ClN6O |
| Molecular Weight | 318.762 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 588.5±60.0 °C at 760 mmHg |
| Melting Point | 192-193℃ |
| Storage Condition | -20℃ |
| Application | BIIB021 is an orally available, fully synthetic HSP90 inhibitor with Ki and EC50 values of 1.7 nM and 38 nM, respectively. |
| HTC | 2933990090 |
| PubChem ID | 26694745 |
| SMILES | COc1c(C)cnc(Cn2cnc3c(Cl)nc(N)nc32)c1C |
| InChI | InChI=1S/C14H15ClN6O/c1-7-4-17-9(8(2)11(7)22-3)5-21-6-18-10-12(15)19-14(16)20-13(10)21/h4,6H,5H2,1-3H3,(H2,16,19,20) |
| InChI Key | QULDDKSCVCJTPV-UHFFFAOYSA-N |
| Use of | BIIB021 is an orally available, fully synthetic inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectively. Properties Name 6-chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]purin-2-amine Synonym More Synonyms BIIB021 Biological Activity Description BIIB021 is an orally available, fully synthetic inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectively. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Cell Cycle/DNA Damage >> HSP Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Research Areas >> Cancer HSP90:1.7 nM (Ki) References [1]. Lundgren, Karen., et al. BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90. Molecular Cancer Therapeutics (2009), 8(4), 921-929. [2]. B?ll B, et al. Heat shock protein 90 inhibitor BIIB021 (CNF2024) depletes NF-kappaB and sensitizes Hodgkin's lymphoma cells for natural killer cell-mediated cytotoxicity. Clin Cancer Res. 2009 Aug 15;15(16):5108-16. [3]. Yin X, et al. BIIB021, a novel Hsp90 inhibitor, sensitizes head and neck squamous cell carcinoma to radiotherapy. Int J Cancer. 2010 Mar 1;126(5):1216-25. [4]. Zhang H, et al. BIIB021, a synthetic Hsp90 inhibitor, has broad application against tumors with acquired multidrug resistance. Int J Cancer. 2010 Mar 1;126(5):1226-34. Chemical & Physical Properties Exact Mass 318.099579 PSA 91.74000 Index of Refraction 1.711 InChIKey QULDDKSCVCJTPV-UHFFFAOYSA-N Storage condition -20℃ Safety Information Hazard Codes Xi HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| POTASSIUM TRIIODIDE ( AQUEOUS SOLUTION -- 75% to 80% ) | 7790-42-3 | 2A-1169105 |
| 2-IODOOCTANE | 629-27-6 | 2A-1169106 |
| 1-IODOHEXADECANE | 544-77-4 | 2A-1169107 |
| 4-Iodo-2,2-dimethyl-tetrahydro-pyran | 882687-80-1 | 2A-1169109 |
| Pre-IBS | 1093215-92-9 | 2A-1169110 |
| 3,4,6-TRI-O-ACETYL-ALPHA-D-GLUCOPYRANOSE 1,2-(METHYL ORTHOACETATE) | 92420-89-8 | 2A-1169117 |
| 4-HYDROXYMETHYL-1,3-DIOXOLAN-2-ONE | 931-40-8 | 2A-1169118 |
| 2-BroMo-4-chloro-5-fluoronitrobenzene | 960000-99-1 | 2A-1169120 |
| ZIRCONIUM CARBONATE | 12340-54-4 | 2A-1169113 |
| SODIUM METATUNGSTATE HYDRATE | 314075-43-9 | 2A-1169123 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS