CAS Number146-56-5
SynonymsMirenil; Fluphenazine hydrochloride; Prolixin; Fluphenazindihydrochlorid; Trancin; Lyorodin; fluorophenazine dihydrochloride; Tensofin; Moditen; Fluphenazine dihydrochloride; fluphenazine dihydrodchloride; MFCD00055212; Anatensol; EINECS 205-674-1; 4-[3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazineethanol dihydrochloride; Fluphenazine (dihydrochloride)
Molecular FormulaC22H28Cl2F3N3OS
Molecular Weight510.44300
Purity98.00%
Boiling Point568.3ºC at 760mmHg
Melting Point200-202ºC
Appearanceoff-white solid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 146-56-5 |
| Catalog No. | 2A-1169041 |
| Chinese Name | 氟非那嗪盐酸盐 |
| Synonyms | Mirenil; Fluphenazine hydrochloride; Prolixin; Fluphenazindihydrochlorid; Trancin; Lyorodin; fluorophenazine dihydrochloride; Tensofin; Moditen; Fluphenazine dihydrochloride; fluphenazine dihydrodchloride; MFCD00055212; Anatensol; EINECS 205-674-1; 4-[3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazineethanol dihydrochloride; Fluphenazine (dihydrochloride) |
| Molecular Formula | C22H28Cl2F3N3OS |
| Molecular Weight | 510.44300 |
| Purity | 98.00 |
| Boiling Point | 568.3ºC at 760mmHg |
| Melting Point | 200-202ºC |
| Appearance | off-white solid |
| Water Solubility | Soluble in DMSO and methanol. |
| Storage Condition | Store sealed in a dry and cool place. |
| Packaging | III |
| Application | Fluphenazine dihydrochloride is a dopamine receptor D1/D2 inhibitor. |
| HTC | 3003909090 |
| PubChem ID | 841991 |
| SMILES | Cl.Cl.OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1 |
| InChI | InChI=1S/C22H26F3N3OS.2ClH/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29;;/h1-2,4-7,16,29H,3,8-15H2;2*1H |
| InChI Key | MBHNWCYEGXQEIT-UHFFFAOYSA-N |
| Hazard Symbols | 6.1 |
| Use of | Fluphenazine dihydrochloride is a phenothiazine-class D1DR and D2DR inhibitor; used to deliver Fluphenazine to biological systems in studies probing the effects and metabolic fates of this commonly used dopamine antagonist. Properties Name 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol,dihydrochloride Synonym More Synonyms Fluphenazine (dihydrochloride) Biological Activity Description Fluphenazine dihydrochloride is a phenothiazine-class D1DR and D2DR inhibitor; used to deliver Fluphenazine to biological systems in studies probing the effects and metabolic fates of this commonly used dopamine antagonist. Related Catalog Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease References [1]. Trzeciak HI, et al. Behavioral effects of withdrawal of fluphenazine after long-term treatment. Arzneimittelforschung. 1976;26(9):1697-700. [2]. Whelpton R, Curry SH. Effect of 20, 6Methods for study of fluphenazine kinetics in man. J Pharm Pharmacol. 1976 Dec;28(12):869-73. [3]. Javaid JI, et al. Fluphenazine determination in human plasma by a sensitive gas chromatographic method using nitrogen detector. J Chromatogr Sci. 1981 Sep;19(9):439-43. Chemical & Physical Properties Exact Mass 509.12800 PSA 55.25000 LogP 5.85290 InChIKey MBHNWCYEGXQEIT-UHFFFAOYSA-N Water Solubility Soluble in DMSO and methanol. Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-, dihydrochloride CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T C666 BN ISJ EXFFF B3- AT6N DNTJ D2Q &GH 2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : DOSE/DURATION : 2800 ug/kg/2W-C TOXIC EFFECTS : Musculoskeletal - other changes TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : male 2 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - other effects on male TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : 92400 ug/kg SEX/DURATION : female 1-39 week(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - drug dependence TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) TYPE OF TEST : Sex chromosome loss and nondisjunction TYPE OF TEST : Micronucleus test TYPE OF TEST : Micronucleus test TYPE OF TEST : Cytogenetic analysis TYPE OF TEST : Cytogenetic analysis MUTATION DATA TYPE OF TEST : Host-mediated assay TEST SYSTEM : Rodent - mouse Bacteria - Salmonella typhimurium DOSE/DURATION : 21250 ug/kg REFERENCE : IRLCDZ IRCS Medical Science: Library Compendium. (Lancaster, UK) V.3-11, 1975-83. For publisher information, see IMSCE2. Volume(issue)/page/year: 8,717,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6052 No. of Facilities: 79 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 2807 (estimated) No. of Female Employees: 1490 (estimated) Safety Information GHS06, GHS08 Signal Word Danger Hazard Statements H301-H360 Precautionary Statements P201-P301 + P310-P308 + P313 Hazard Codes Xn: Harmful; RIDADR UN2811 RTECS TL9800000 Packaging Group III Hazard Class 6.1 HS Code 3003909090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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