CAS Number27113-22-0
Synonyms[6]-Paradol; 7V2R DQ CO1; EINECS 248-228-1; 1-(4-hydroxy-3-methoxy-phenyl)-decan-3-one; 3-Decanone,1-(4-hydroxy-3-methoxyphenyl); 5-Paradol; 1-(4-Hydroxy-3-methoxyphenyl)-3-decanone; 1-(4-hydroxy-3-methoxyphenyl)decan-5-one; 1-(4-Hydroxy-3-methoxy-phenyl)-decan-3-on; 6-Paradol; Paradol
Molecular FormulaC17H26O3
Molecular Weight278.387
Purity97%
Density1.0±0.1 g/cm3
Boiling Point406.5±30.0 °C at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 27113-22-0 |
| Catalog No. | 2A-1169012 |
| Chinese Name | 非洲豆蔻醇 |
| Synonyms | [6]-Paradol; 7V2R DQ CO1; EINECS 248-228-1; 1-(4-hydroxy-3-methoxy-phenyl)-decan-3-one; 3-Decanone,1-(4-hydroxy-3-methoxyphenyl); 5-Paradol; 1-(4-Hydroxy-3-methoxyphenyl)-3-decanone; 1-(4-hydroxy-3-methoxyphenyl)decan-5-one; 1-(4-Hydroxy-3-methoxy-phenyl)-decan-3-on; 6-Paradol; Paradol |
| Molecular Formula | C17H26O3 |
| Molecular Weight | 278.387 |
| Purity | 97 |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 406.5±30.0 °C at 760 mmHg |
| Storage Condition | -20°C |
| Application | Paradol is a pungent phenolic compound found in plants of the ginger family. In mouse skin cancer, Paradol binds to the active site of cyclooxygenase (COX-2) and effectively inhibits tumor development |
| HTC | 2914509090 |
| PubChem ID | 12665 |
| SMILES | CCCCCCCC(=O)CCc1ccc(O)c(OC)c1 |
| InChI | InChI=1S/C17H26O3/c1-3-4-5-6-7-8-15(18)11-9-14-10-12-16(19)17(13-14)20-2/h10,12-13,19H,3-9,11H2,1-2H3 |
| InChI Key | CZNLTCTYLMYLHL-UHFFFAOYSA-N |
| Use of | Paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants. Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds to cyclooxygenase (COX)-2 active site. Properties Name 1-(4-hydroxy-3-methoxyphenyl)decan-3-one Synonym More Synonyms Paradol Biological Activity Description Paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants. Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds to cyclooxygenase (COX)-2 active site. Related Catalog Signaling Pathways >> Immunology/Inflammation >> COX Research Areas >> Cancer Natural Products >> Phenols In Vitro Paradol ([6]-paradol) induces apoptosis in an oral squamous carcinoma cell line, KB, in a dose-dependent manner. Paradol induces apoptosis through a caspase-3-dependent mechanism[2]. References [1]. van Breemen RB, et al. Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale). Fitoterapia. 2011 Jan;82(1):38-43. [2]. Keum YS, et al. Induction of apoptosis and caspase-3 activation by chemopreventive [6]-paradol and structurally related compounds in KB cells. Cancer Lett. 2002 Mar 8;177(1):41-7. [3]. Gaire BP, et al. Neuroprotective effect of 6-paradol in focal cerebral ischemia involves the attenuation of neuroinflammatory responses in activated microglia. PLoS One. 2015 Mar 19;10(3):e0120203. [4]. Setoguchi S, et al. Pharmacokinetics of Paradol Analogues Orally Administered to Rats. J Agric Food Chem. 2016 Mar 9;64(9):1932-7. Chemical & Physical Properties Molecular Formula C17H26O3 Exact Mass 278.188202 PSA 46.53000 Index of Refraction 1.507 InChIKey CZNLTCTYLMYLHL-UHFFFAOYSA-N Safety Information HS Code 2914509090 Synthetic Route Total: 1 Page dehydroparadol CAS#:53172-10-4 CAS#:27113-22-0 Literature: Locksley,H.D. et al. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1972 , p. 3001 - 3006 2-Nonanone CAS#:821-55-6 CAS#:27113-22-0 Literature: Locksley,H.D. et al. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1972 , p. 3001 - 3006 CAS#:121-33-5 CAS#:27113-22-0 Literature: Locksley,H.D. et al. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1972 , p. 3001 - 3006 Precursor & DownStream Precursor 3 CAS#:53172-10-4 dehydroparadol CAS#:821-55-6 2-Nonanone CAS#:121-33-5 DownStream 0 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
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