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Crenolanib structure, CAS 670220-88-9

Crenolanib

CAS Number670220-88-9

Synonyms1-{2-[5-(3-methyloxetan-3-ylmethoxy)benzoimidazol-1-yl]quinolin-8-yl}piperidin-4-ylamine; 1-[2-[5-[(3-methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine; ARO-002; Crenolanib; 1-(2-{5-[(3-Methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl}-8-quinolinyl)-4-piperidinamine; cc-84; 1-(2-{5-[(3-methyloxetan-3-yl)methoxy]-1H-benzimidazol-1-yl}quinolin-8-yl)piperidin-4-amine; UNII-LQF7I567TQ; CP 868596; CP868596

Molecular FormulaC26H29N5O2

Molecular Weight443.541

Purity

Density1.4±0.1 g/cm3

Boiling Point676.6±65.0 °C at 760 mmHg

Melting Point

Flash Point

AppearanceOff-white to light green solid

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-1168965 Purity:
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COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number670220-88-9
Catalog No.2A-1168965
Chinese Name[1-[2-[5-(3-甲基氧杂环丁烷-3-基甲氧基)苯并咪唑-1-基]喹啉-8-基]哌啶-4-基]胺
Synonyms1-{2-[5-(3-methyloxetan-3-ylmethoxy)benzoimidazol-1-yl]quinolin-8-yl}piperidin-4-ylamine; 1-[2-[5-[(3-methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine; ARO-002; Crenolanib; 1-(2-{5-[(3-Methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl}-8-quinolinyl)-4-piperidinamine; cc-84; 1-(2-{5-[(3-methyloxetan-3-yl)methoxy]-1H-benzimidazol-1-yl}quinolin-8-yl)piperidin-4-amine; UNII-LQF7I567TQ; CP 868596; CP868596
Molecular FormulaC26H29N5O2
Molecular Weight443.541
Density1.4±0.1 g/cm3
Boiling Point676.6±65.0 °C at 760 mmHg
AppearanceOff-white to light green solid
Storage Condition-20℃
ApplicationCrenolanib is a potent and selective inhibitor of wild-type and mutant class III receptor tyrosine kinases, with Kds of 0.74 nM, 2.1 nM, and 3.2 nM for FLT3 and PDGFRα/β, respectively.
PubChem ID15379617
SMILESCC1(COc2ccc3c(c2)ncn3-c2ccc3cccc(N4CCC(N)CC4)c3n2)COC1
InChIInChI=1S/C26H29N5O2/c1-26(14-32-15-26)16-33-20-6-7-22-21(13-20)28-17-31(22)24-8-5-18-3-2-4-23(25(18)29-24)30-11-9-19(27)10-12-30/h2-8,13,17,19H,9-12,14-16,27H2,1H3
InChI KeyDYNHJHQFHQTFTP-UHFFFAOYSA-N
Transport InfoProduct name: Clarani
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