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Home > Products > Pharmaceutical R&D Materials > Heterocyclic Building Blocks > N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(tert-butyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide
N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(tert-butyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide structure, CAS 1195765-45-7

N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(tert-butyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide

CAS Number1195765-45-7

SynonymsUNII-QGP4HA4G1B; Tafinlar; Dabrafenib; Dabrafenib (USAN); Dabrafenib [USAN:INN]; GSK2118436

Molecular FormulaC23H20F3N5O2S2

Molecular Weight519.562

Purity98%

Density1.4±0.1 g/cm3

Boiling Point653.7±65.0 °C at 760 mmHg

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Cat. No.: 2A-1168866 Purity: 98%
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Quality Control of [ 1195765-45-7 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number1195765-45-7
Catalog No.2A-1168866
Chinese Name达拉菲尼
SynonymsUNII-QGP4HA4G1B; Tafinlar; Dabrafenib; Dabrafenib (USAN); Dabrafenib [USAN:INN]; GSK2118436
Molecular FormulaC23H20F3N5O2S2
Molecular Weight519.562
Purity98
Density1.4±0.1 g/cm3
Boiling Point653.7±65.0 °C at 760 mmHg
Storage Condition-20°C
ApplicationDabrafenib is an ATP-competitive Raf inhibitor with IC50s of 5 nM and 0.6 nM for inhibiting C-Raf and B-RafV600E, respectively.
PubChem ID85742096
SMILESCC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(N)n2)s1
InChIInChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29)
InChI KeyBFSMGDJOXZAERB-UHFFFAOYSA-N
Transport InfoProduct Name: Dabrafenib
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