| Chemical & Physical Properties | |
|---|---|
| CAS Number | 934660-93-2 |
| Catalog No. | 2A-1168642 |
| Chinese Name | 考比替尼 |
| Synonyms | Cotellic; Cobimetinib; XL518; RG 7420; GDC 0973; EUI; GDC-0973 |
| Molecular Formula | C21H21F3IN3O2 |
| Molecular Weight | 531.310 |
| Density | 1.7±0.1 g/cm3 |
| Boiling Point | 565.9±50.0 °C at 760 mmHg |
| Appearance | White to off-white powder |
| Storage Condition | -20℃ |
| Application | Cobimetinib (GDC-0973, RG7420) is a potent, selective, orally available MEK inhibitor with an IC50 of 4.2 nM for MEK1 inhibition. |
| PubChem ID | 24904580 |
| SMILES | O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)(C2CCCCN2)C1 |
| InChI | InChI=1S/C21H21F3IN3O2/c22-14-6-5-13(19(18(14)24)27-16-7-4-12(25)9-15(16)23)20(29)28-10-21(30,11-28)17-3-1-2-8-26-17/h4-7,9,17,26-27,30H,1-3,8,10-11H2/t17-/m0/s1 |
| InChI Key | BSMCAPRUBJMWDF-KRWDZBQOSA-N |
| Transport Info | Product Name: Cobimetinib |
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