CAS Number149709-62-6
Synonyms4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoic acid; AHU-377; ENTRESTO; 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid; 4-{[(2S,4R)-1-(4-Biphenylyl)-5-ethoxy-4-methyl-5-oxo-2-pentanyl]amino}-4-oxobutanoic acid; AHU377; Sacubitril
Molecular FormulaC24H29NO5
Molecular Weight411.491
Density1.2±0.1 g/cm3
Boiling Point656.9±55.0 °C at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 149709-62-6 |
| Catalog No. | 2A-1168589 |
| Chinese Name | 沙库比曲 |
| Synonyms | 4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoic acid; AHU-377; ENTRESTO; 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid; 4-{[(2S,4R)-1-(4-Biphenylyl)-5-ethoxy-4-methyl-5-oxo-2-pentanyl]amino}-4-oxobutanoic acid; AHU377; Sacubitril |
| Molecular Formula | C24H29NO5 |
| Molecular Weight | 411.491 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 656.9±55.0 °C at 760 mmHg |
| Storage Condition | room temperature, dry |
| Application | Sacubitril (AHU-377) is a potent NEP inhibitor with an IC50 value of 5 nM. Sacubitril (AHU-377) is a component of the heart failure drug LCZ696. |
| PubChem ID | 26673060 |
| SMILES | CCOC(=O)C(C)CC(Cc1ccc(-c2ccccc2)cc1)NC(=O)CCC(=O)O |
| InChI | InChI=1S/C24H29NO5/c1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19/h4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28)/t17-,21+/m1/s1 |
| InChI Key | PYNXFZCZUAOOQC-UTKZUKDTSA-N |
| Transport Info | Product name: AHU 377 |
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| FIM8 Hydroxy(3C) | 2A-1168584 | 2A-1168584 |
| FIM8 Nonane | 2A-1168585 | 2A-1168585 |
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| SOLIFENACIN | 180272-14-4 | 2A-1168592 |
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| morpholin-3-ol | 2A-1168609 | 2A-1168609 |
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