CAS Number61-80-3
SynonymsEINECS 200-519-4; MFCD00005770; 5-chloro-1,3-benzoxazol-2-amine; Zoxazolamine
Molecular FormulaC7H5ClN2O
Molecular Weight168.58
Purity97%
Density1.481 g/cm3
Boiling Point316.8ºC at 760 mmHg
Melting Point181-184 °C (lit.)
Appearancepowder
EINECS200-519-4
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 61-80-3 |
| Catalog No. | 2A-9016864 |
| Chinese Name | 苯并恶唑胺 |
| Synonyms | EINECS 200-519-4; MFCD00005770; 5-chloro-1,3-benzoxazol-2-amine; Zoxazolamine |
| Molecular Formula | C7H5ClN2O |
| Molecular Weight | 168.58 |
| Purity | 97 |
| Density | 1.481 g/cm3 |
| Boiling Point | 316.8ºC at 760 mmHg |
| Melting Point | 181-184 °C (lit.) |
| Appearance | powder |
| Storage Condition | Sealed in a cool, dry environment. |
| Application | Zoxazolamine is widely used in drug testing as a convenient indicator of changes in cytochrome P-450 activity in rodents. |
| EINECS | 200-519-4 |
| HTC | 2934999090 |
| PubChem ID | 24890884 |
| MDL Number | MFCD00005770 |
| SMILES | Nc1nc2cc(Cl)ccc2o1 |
| InChI | 1S/C7H5ClN2O/c8-4-1-2-6-5(3-4)10-7(9)11-6/h1-3H,(H2,9,10) |
| InChI Key | YGCODSQDUUUKIV-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | Transport |
| MSDS | msds/16864_1_61_80_3.pdf |
| Bioactivity | Zoxazolamine is widely used for a pharmacologic test that serves as a convenient indicator of changes in cytochrome P-450 activity in rodents. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease In Vivo Zoxazolamine is widely used for a pharmacologic test that serves as a convenient indicator of changes in cytochrome P-450 activity in rodents. The time-averaged serum clearance determined from tested concentrations data is 7.22±1.01 mL/min/kg for Zoxazolamine. Infusion of Zoxazolamine to righting reflex (LRR) at three different rates shows increasing Zoxazolamine concentration in serum and brain at the onset of the effect with increasing infusion rates. When the Zoxazolamine infusion is continued for 5 min beyond the onset of LRR, the concentrations of Zoxazolamine in the cerebrospinal fluid (CSF) at the offset of LRR are essentially identical to the onset concentrations[1]. Animal Admin Inbred male Lewis rats are used in this study. The animals are allowed 7 to 12 days to adjust to the local animal facilities and to recover possible stress incurred during transport. To compare drug concentrations in serum at the onset and offset of loss of the righting reflex, Zoxazolamine is infused into the femoral vein at a rate of 0.51 mg/min for 5 min beyond the onset of loss of the righting reflex. The infusion solution consists of 10 mg Zoxazolamine in 1 mL normal saline. Then, blood samples from the jugular vein are obtained from four rates at the onset and offset of loss of the righting reflex, using a procedure that yields mainstream blood[1]. References [1]. Yasuhara M, et al. Pharmacodynamics of zoxazolamine and chlorzoxazone in rats. Pharm Res. 1988 Jul;5(7):401-7. Chemical & Physical Properties Density 1.481 g/cm3 Boiling Point 316.8ºC at 760 mmHg Melting Point 181-184 °C(lit.) Molecular Formula C7H5ClN2O Molecular Weight 168.58000 Flash Point 145.4ºC Exact Mass 168.00900 PSA 52.05000 LogP 2.64460 Index of Refraction 1.692 InChIKey YGCODSQDUUUKIV-UHFFFAOYSA-N SMILES Nc1nc2cc(Cl)ccc2o1 |
| Use of | Zoxazolamine is widely used for a pharmacologic test that serves as a convenient indicator of changes in cytochrome P-450 activity in rodents. Properties Articles25 Name 2-Amino-5-chlorobenzoxazole Synonym More Synonyms Zoxazolamine Biological Activity Description Zoxazolamine is widely used for a pharmacologic test that serves as a convenient indicator of changes in cytochrome P-450 activity in rodents. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease References [1]. Yasuhara M, et al. Pharmacodynamics of zoxazolamine and chlorzoxazone in rats. Pharm Res. 1988 Jul;5(7):401-7. Chemical & Physical Properties Exact Mass 168.00900 PSA 52.05000 LogP 2.64460 Index of Refraction 1.692 InChIKey YGCODSQDUUUKIV-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Cyclic AMP | 60-92-4 | 2A-9016850 |
| Sodium naphthalene-1-acetate | 61-31-4 | 2A-9016855 |
| N,N-Dimethyltryptamine | 61-50-7 | 2A-9016857 |
| N,N-Dipropyltryptamine | 61-52-9 | 2A-9016858 |
| Tryptamine | 61-54-1 | 2A-9016859 |
| Adrenalone hydrochloride | 62-13-5 | 2A-9016867 |
| EDTA calcium disodium | 62-33-9 | 2A-9016870 |
| Phenacetin | 62-44-2 | 2A-9016871 |
| Ethyl methanesulfonate | 62-50-0 | 2A-9016873 |
| Sodium oxalate | 62-76-0 | 2A-9016880 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS