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Home > Products > Specialty & Industrial Chemicals > Specialty Chemicals > 15-Deoxy-Δ12,14-prostaglandin
15-Deoxy-Δ12,14-prostaglandin structure, CAS 87893-55-8

15-Deoxy-Δ12,14-prostaglandin

CAS Number87893-55-8

Synonymsdelta12,14-Pgj 2; 15-Deoxy-D-12,14-prostaglandin J2; 15-Deoxy-D12,14-PGJ2; PROSTAGLANDIN J2,15-DEOXY-DELTA12,14; 11-OXO-PROSTA-5Z,9,12E,14Z-TETRAEN-1-OIC; 15-DEOXY-DELTA12,14-PROSTAGLANGIN J2; 15-DEOXY-DELTA12,14-PGJ2; MFCD00065806; 15-DEOXY-DELTA12,DELTA14-PROSTAGLANDIN J2; (5Z,12E,14E)-11-Oxo-prosta-5,9,12,14-tetraen-1-oic acid; 15-Deoxy-delta12,14-prostaglandin; (5Z,12E,14E)-11-Oxoprosta-5,9,12,14-tetraen-1-oic acid

Molecular FormulaC20H28O3

Molecular Weight316.435

Purity

Density1.1±0.1 g/cm3

Boiling Point495.8±34.0 °C at 760 mmHg

Melting Point

Flash Point

Appearanceoily

EINECS

MSDSChineseEnglish

Symboltransportation

Signal WordWarning

Cat. No.: 2A-1168401 Purity:
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Quality Control of [ 87893-55-8 ] SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number87893-55-8
Catalog No.2A-1168401
Chinese Name15-脱氧-Δ12,14-前列腺素J2
Synonymsdelta12,14-Pgj 2; 15-Deoxy-D-12,14-prostaglandin J2; 15-Deoxy-D12,14-PGJ2; PROSTAGLANDIN J2,15-DEOXY-DELTA12,14; 11-OXO-PROSTA-5Z,9,12E,14Z-TETRAEN-1-OIC; 15-DEOXY-DELTA12,14-PROSTAGLANGIN J2; 15-DEOXY-DELTA12,14-PGJ2; MFCD00065806; 15-DEOXY-DELTA12,DELTA14-PROSTAGLANDIN J2; (5Z,12E,14E)-11-Oxo-prosta-5,9,12,14-tetraen-1-oic acid; 15-Deoxy-delta12,14-prostaglandin; (5Z,12E,14E)-11-Oxoprosta-5,9,12,14-tetraen-1-oic acid
Molecular FormulaC20H28O3
Molecular Weight316.435
Density1.1±0.1 g/cm3
Boiling Point495.8±34.0 °C at 760 mmHg
Appearanceoily
Storage Condition-20°C refrigerated, airtight, dry place
Application15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a metabolite of cyclopentenone prostaglandin and PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 µM) and covalent PPARδ agonist.
PubChem ID616280
SMILESCCCCCC=CC=C1C(=O)C=CC1CC=CCCCC(=O)O
InChIInChI=1S/C20H28O3/c1-2-3-4-5-6-10-13-18-17(15-16-19(18)21)12-9-7-8-11-14-20(22)23/h6-7,9-10,13,15-17H,2-5,8,11-12,14H2,1H3,(H,22,23)/b9-7-,10-6+,18-13+/t17-/m0/s1
InChI KeyVHRUMKCAEVRUBK-GODQJPCRSA-N
Hazard Symbolstransportation
MSDSmsds/168452_2_87893_55_8.pdf
Bioactivity15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease Target PPARγ:2 μM (EC50) PPARδ Human Endogenous Metabolite In Vitro 15-Deoxy-Δ12,14-PGJ2 (15d-PGJ2) is a cyclopentenone prostaglandin that features an electrophilic, α, β-unsaturated ketone (an enone) in the cyclopentenone ring. 15-Deoxy-Δ-12,14-prostaglandin J2 is one of the cyPGs whose functions in inflammation, cell proliferation, survival, and apoptosis have been documented. 15-Deoxy-Δ-12,14-prostaglandin J2 activates PPARδ in a dose-dependent manner. 15-Deoxy-Δ-12,14-prostaglandin J2 activates PPARδ's transcriptional activity through formation of a covalent adduct between its endocyclic enone at C9 and Cys249 in the receptor's ligand-binding domain[1]. References [1]. Reddy AT, et al. Identification and Molecular Characterization of Peroxisome Proliferator-Activated Receptor δ as a Novel Target for Covalent Modification by 15-Deoxy-Δ12,14-prostaglandin J2. CS Chem Biol. 2018 Dec 21;13(12):3269-3278. [2]. Kliewer SA1, et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell. 1995 Dec 1;83(5):813-9. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 495.8±34.0 °C at 760 mmHg Molecular Formula C20H28O3 Molecular Weight 316.435 Flash Point 267.8±22.2 °C Exact Mass 316.203857 PSA 54.37000 LogP 5.10 Vapour Pressure 0.0±2.7 mmHg at 25°C Index of Refraction 1.558 InChIKey VHRUMKCAEVRUBK-GODQJPCRSA-N SMILES CCCCCC=CC=C1C(=O)C=CC1CC=CCCCC(=O)O
Use ofProperties Articles12 Name 15d-pgj2 Synonym More Synonyms 15-Deoxy-Delta12 Biological Activity Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease PPARγ:2 μM (EC50) Human Endogenous Metabolite In Vitro 15-Deoxy-Δ12,14-PGJ2 (15d-PGJ2) is a cyclopentenone prostaglandin that features an electrophilic, α, β-unsaturated ketone (an enone) in the cyclopentenone ring. 15-Deoxy-Δ-12,14-prostaglandin J2 is one of the cyPGs whose functions in inflammation, cell proliferation, survival, and apoptosis have been documented. 15-Deoxy-Δ-12,14-prostaglandin J2 activates PPARδ in a dose-dependent manner. 15-Deoxy-Δ-12,14-prostaglandin J2 activates PPARδ's transcriptional activity through formation of a covalent adduct between its endocyclic enone at C9 and Cys249 in the receptor's ligand-binding domain[1]. References Chemical & Physical Properties Molecular Formula C20H28O3 Exact Mass 316.203857 PSA 54.37000 Index of Refraction 1.558 InChIKey VHRUMKCAEVRUBK-GODQJPCRSA-N
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 1231 International Dangerous Regulations for sea transport: 1231 International Dangerous Regulations for air transport: 1231 14.2 United Nations shipping name European Land Transport Danger Regulation: METHYL ACETATE IMDG: METHYL ACETATE International air transport hazard regulations: Methyl acetate 14.3 Transport hazard categories European land transport Dangerous Regulations: 3 International sea transport Dangerous Regulations: 3 International air transport Dangerous Regulations: 3 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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