CAS Number486-84-0
Synonyms1-Methyl-9H-β-carboline; 2-Methyl-b-carboline; Harmane; Aribine; MFCD00004957; Harman; 1-Methyl-β-carboline; 1-methylbetacarboline; Aribin; 1-Methyl-9H-pyrid[3,4-b]indole; EINECS 207-642-2; Passiflorin; Loturine; 1-methyl-9H-pyrido[3,4-b]indole; 1-Me-carboline; Locuturine; Locuturin; Phorbol 12,13-dibutyrate
Molecular FormulaC12H10N2
Molecular Weight182.221
Purity98.00%
Density1.3±0.1 g/cm3
Boiling Point386.9±22.0 °C at 760 mmHg
Melting Point235-238 °C(lit.)
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 486-84-0 |
| Catalog No. | 2A-1167845 |
| Chinese Name | 哈尔满碱 |
| Synonyms | 1-Methyl-9H-β-carboline; 2-Methyl-b-carboline; Harmane; Aribine; MFCD00004957; Harman; 1-Methyl-β-carboline; 1-methylbetacarboline; Aribin; 1-Methyl-9H-pyrid[3,4-b]indole; EINECS 207-642-2; Passiflorin; Loturine; 1-methyl-9H-pyrido[3,4-b]indole; 1-Me-carboline; Locuturine; Locuturin; Phorbol 12,13-dibutyrate |
| Molecular Formula | C12H10N2 |
| Molecular Weight | 182.221 |
| Purity | 98.00 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 386.9±22.0 °C at 760 mmHg |
| Melting Point | 235-238 °C(lit.) |
| Appearance | powder |
| Storage Condition | Use and store according to specifications, will no |
| Packaging | III |
| Application | Harmane, a beta-carboline alkaloid (BCA), is a potent neurotoxin that can cause severe movement tremors and psychiatric manifestations. Harmane is 1000 times more selective for the I1-Imidazoline rece |
| HTC | 2933990090 |
| SMILES | Cc1nccc2c1[nH]c1ccccc12 |
| InChI | InChI=1S/C12H10N2/c1-8-12-10(6-7-13-8)9-4-2-3-5-11(9)14-12/h2-7,14H,1H3 |
| InChI Key | PSFDQSOCUJVVGF-UHFFFAOYSA-N |
| Hazard Symbols | 6.1(b) |
| Bioactivity | Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively). Harmane exhibits comutagenic effect[1][2][3][4]. Related Catalog Signaling Pathways >> Neuronal Signaling >> Imidazoline Receptor Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Imidazoline Receptor Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease Target hMAO-A:0.5 μM (IC50) MAO-B:5 μM (IC50) α2-adrenergic receptor:18 μM (IC50) I1-Imidazoline receptor:30 nM (IC50) References [1]. Louis ED, et, al. Blood harmane concentrations and dietary protein consumption in essential tremor. Neurology. 2005 Aug 9;65(3):391-6. [2]. Musgrave IF, et, al. Harmane produces hypotension following microinjection into the RVLM: possible role of I(1)-imidazoline receptors. Br J Pharmacol. 2000 Mar;129(6):1057-9. [3]. Glover V, et, al. β-Carbolines as selective monoamine oxidase inhibitors:In vivo implications [4]. Umezawa K, et, al. Comutagenic effect of norharman and harman with 2-acetylaminofluorene derivatives. Proc Natl Acad Sci U S A. 1978 Feb;75(2):928-30. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 386.9±22.0 °C at 760 mmHg Melting Point 235-238 °C(lit.) Molecular Formula C12H10N2 Molecular Weight 182.221 Flash Point 176.2±13.6 °C Exact Mass 182.084396 PSA 28.68000 LogP 3.26 Vapour Pressure 0.0±0.8 mmHg at 25°C Index of Refraction 1.750 InChIKey PSFDQSOCUJVVGF-UHFFFAOYSA-N SMILES Cc1nccc2c1[nH]c1ccccc12 |
| Use of | Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively). Harmane exhibits comutagenic effect[1][2][3][4]. Properties Articles47 Name harman Synonym More Synonyms Harmane Biological Activity Description Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively). Harmane exhibits comutagenic effect[1][2][3][4]. Related Catalog Signaling Pathways >> Neuronal Signaling >> Imidazoline Receptor Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Imidazoline Receptor Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease hMAO-A:0.5 μM (IC50) MAO-B:5 μM (IC50) α2-adrenergic receptor:18 μM (IC50) I1-Imidazoline receptor:30 nM (IC50) References [1]. Louis ED, et, al. Blood harmane concentrations and dietary protein consumption in essential tremor. Neurology. 2005 Aug 9;65(3):391-6. [2]. Musgrave IF, et, al. Harmane produces hypotension following microinjection into the RVLM: possible role of I(1)-imidazoline receptors. Br J Pharmacol. 2000 Mar;129(6):1057-9. [3]. Glover V, et, al. β-Carbolines as selective monoamine oxidase inhibitors:In vivo implications [4]. Umezawa K, et, al. Comutagenic effect of norharman and harman with 2-acetylaminofluorene derivatives. Proc Natl Acad Sci U S A. 1978 Feb;75(2):928-30. Chemical & Physical Properties Molecular Formula C12H10N2 Exact Mass 182.084396 PSA 28.68000 Index of Refraction 1.750 InChIKey PSFDQSOCUJVVGF-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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