CAS Number147-20-6
SynonymsHispril; N-methyl-4-(diphenylmethoxy)piperidine; Neargal; Lergobine; EINECS 205-686-7; Belfene; Dayfen; 4-benzhydryloxy-1-methyl-piperidine; Histyn; Mepiben; 4-Benzhydryloxy-1-methyl-piperidin; 4-Diphenylmethoxy-1-methyl-piperidin; 4-(diphenylmethoxy)-1-methylpiperidine; Lyssipoll; Allergen; 4-benzhydryloxy-1-methylpiperidine
Molecular FormulaC19H23NO
Molecular Weight281.39200
Purity98%
Density1.08 g/cm3
Boiling Point378.7ºC at 760 mmHg
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 147-20-6 |
| Catalog No. | 2A-1166745 |
| Chinese Name | 4-(苯甲酰氧基)-1-甲基哌啶 |
| Synonyms | Hispril; N-methyl-4-(diphenylmethoxy)piperidine; Neargal; Lergobine; EINECS 205-686-7; Belfene; Dayfen; 4-benzhydryloxy-1-methyl-piperidine; Histyn; Mepiben; 4-Benzhydryloxy-1-methyl-piperidin; 4-Diphenylmethoxy-1-methyl-piperidin; 4-(diphenylmethoxy)-1-methylpiperidine; Lyssipoll; Allergen; 4-benzhydryloxy-1-methylpiperidine |
| Molecular Formula | C19H23NO |
| Molecular Weight | 281.39200 |
| Purity | 98 |
| Density | 1.08 g/cm3 |
| Boiling Point | 378.7ºC at 760 mmHg |
| Storage Condition | room temperature |
| Packaging | III |
| Application | Diphenylpyraline is a potent histamine H1 receptor antagonist. Diphenylpyraline is an orally active antihistamine agent with anticholinergic and antiallergic effects. Diphenylpyraline can be used in t |
| HTC | 2933399090 |
| PubChem ID | 615228 |
| SMILES | CN1CCC(OC(c2ccccc2)c2ccccc2)CC1 |
| InChI | InChI=1S/C19H23NO/c1-20-14-12-18(13-15-20)21-19(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18-19H,12-15H2,1H3 |
| InChI Key | OWQUZNMMYNAXSL-UHFFFAOYSA-N |
| Hazard Symbols | 6.1(b) |
| Use of | Diphenylpyraline is a potent histamine H1 receptor antagonist. Diphenylpyraline acts as an orally active antihistamine agent with antimuscarinic and antiallergic effects. Diphenylpyraline can be used for the research of allergic diseases, including rhinitis and hay fever, and pruritic skin disorders et.al[1]. Properties Name diphenylpyraline Synonym More Synonyms diphenylpyraline Biological Activity Description Diphenylpyraline is a potent histamine H1 receptor antagonist. Diphenylpyraline acts as an orally active antihistamine agent with antimuscarinic and antiallergic effects. Diphenylpyraline can be used for the research of allergic diseases, including rhinitis and hay fever, and pruritic skin disorders et.al[1]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor H1 Receptor In Vitro Diphenylpyraline (10 μM) markedly inhibits dopamine uptakein mouse nucleus accumbens slices[2]. References [1]. Erik B Oleson, et al. Effects of the histamine H₁ receptor antagonist and benztropine analog diphenylpyraline on dopamine uptake, locomotion and reward. [2]. Gennady B Lapa, et al. Diphenylpyraline, a histamine H1 receptor antagonist, has psychostimulant properties. Chemical & Physical Properties Molecular Formula C19H23NO Exact Mass 281.17800 PSA 12.47000 LogP 3.82470 Index of Refraction 1.587 InChIKey OWQUZNMMYNAXSL-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Piperidine, 4-(diphenylmethoxy)-1-methyl- CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C19-H23-N-O MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T6NTJ A1 DOYR&R HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Rodent - rabbit REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 50,459,1979 ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 26,155,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 26,1203,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84788 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 62 (estimated) Safety Information Hazard Codes Xn RIDADR UN 3249 Packaging Group III Hazard Class 6.1(b) HS Code 2933399090 Precursor & DownStream Precursor 3 CAS#:106-52-5 1-Methyl-4-pipe... CAS#:776-74-9 Bromodiphenylmethane CAS#:90-99-3 benzhydryl chloride DownStream 2 CAS#:58258-01-8 4-(Diphenylmeth... CAS#:65214-84-8 ethyl 4-benzhyd... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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