CAS Number546-06-5
Synonyms3β-(Dimethylamino)con-5-enine; 3-β-(Dimethylamino)con-5-enine; CONESSIN; Conessine; Konessin; ROGUESSINE; Conessine,N,N-Dimethyl-con-5-enin-3-amine; (3β)-N,N-Dimethylcon-5-enin-3-amine; ROQUESSINE; Wrightine; NERVINE; 3β-(Dimethylamino)con-5-ene; (3b)-N,N-Dimethylcon-5-enin-3-amine; 3b-(Dimethylamino)con-5-enine; NERIINE; 1-Deazaadenosine; 5-CONENIN-3BETA-DIMETHYLAMINE
Molecular FormulaC24H40N2
Molecular Weight356.588
Density1.1±0.1 g/cm3
Boiling Point450.4±45.0 °C at 760 mmHg
Melting Point126-127ºC
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 546-06-5 |
| Catalog No. | 2A-1166738 |
| Chinese Name | 康里新 |
| Synonyms | 3β-(Dimethylamino)con-5-enine; 3-β-(Dimethylamino)con-5-enine; CONESSIN; Conessine; Konessin; ROGUESSINE; Conessine,N,N-Dimethyl-con-5-enin-3-amine; (3β)-N,N-Dimethylcon-5-enin-3-amine; ROQUESSINE; Wrightine; NERVINE; 3β-(Dimethylamino)con-5-ene; (3b)-N,N-Dimethylcon-5-enin-3-amine; 3b-(Dimethylamino)con-5-enine; NERIINE; 1-Deazaadenosine; 5-CONENIN-3BETA-DIMETHYLAMINE |
| Molecular Formula | C24H40N2 |
| Molecular Weight | 356.588 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 450.4±45.0 °C at 760 mmHg |
| Melting Point | 126-127ºC |
| Storage Condition | Store in a cool, dry, well-ventilated warehouse. K |
| Application | Conessine is a steroidal alkaloid with Kis of 5.4, 6.0, 5.7 and 25 nM for human, dog, guinea pig and rat H3 receptors respectively. It is a potent and selective histamine H3 receptor antagonist. Anti- |
| SMILES | CC1C2CCC3C4CC=C5CC(N(C)C)CCC5(C)C4CCC32CN1C |
| InChI | InChI=1S/C24H40N2/c1-16-20-8-9-22-19-7-6-17-14-18(25(3)4)10-12-23(17,2)21(19)11-13-24(20,22)15-26(16)5/h6,16,18-22H,7-15H2,1-5H3/t16-,18-,19+,20+,21-,22-,23-,24-/m0/s1 |
| InChI Key | GPLGAQQQNWMVMM-MYAJQUOBSA-N |
| Hazard Symbols | transportation |
| Bioactivity | Conessine, a steroidal alkaloid, is a potent and selective histamine H3 receptor antagonist with Kis of 5.4, 6.0, 5.7 and 25 nM for human, dog, guinea pig, and rat H H3 receptor, respectively. Anti-malarial activity[1]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Infection Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Target H3 Receptor:5.4 nM (Ki) rat H3 receptor:25 nM (Ki) Guinea pig H3 Receptor:6.0 nM (Ki) Dog H3 Receptor:5.7 nM (Ki) References [1]. Santora VJ, et al. A new family of H3 receptor antagonists based on the natural product Conessine. Bioorg Med Chem Lett. 2008;18(4):1490-1494. [2]. Kim H, et al. Conessine treatment reduces dexamethasone-induced muscle atrophy by regulating MuRF1 and atrogin-1 expression [published online ahead of print, 2018 Feb 1]. J Microbiol Biotechnol. 2018;10.4014.jmb.1711.11009. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 450.4±45.0 °C at 760 mmHg Melting Point 126-127ºC Molecular Formula C24H40N2 Molecular Weight 356.588 Flash Point 199.6±16.5 °C Exact Mass 356.319153 PSA 6.48000 LogP 5.71 Vapour Pressure 0.0±1.1 mmHg at 25°C Index of Refraction 1.564 InChIKey GPLGAQQQNWMVMM-MYAJQUOBSA-N SMILES CC1C2CCC3C4CC=C5CC(N(C)C)CCC5(C)C4CCC32CN1C |
| Use of | Conessine, a steroidal alkaloid, is a potent and selective histamine H3 receptor antagonist with Kis of 5.4, 6.0, 5.7 and 25 nM for human, dog, guinea pig, and rat H H3 receptor, respectively. Anti-malarial activity[1]. Properties Articles23 Name conessine Synonym More Synonyms Conessine Biological Activity Description Conessine, a steroidal alkaloid, is a potent and selective histamine H3 receptor antagonist with Kis of 5.4, 6.0, 5.7 and 25 nM for human, dog, guinea pig, and rat H H3 receptor, respectively. Anti-malarial activity[1]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Infection Signaling Pathways >> GPCR/G Protein >> Histamine Receptor H3 Receptor:5.4 nM (Ki) rat H3 receptor:25 nM (Ki) Guinea pig H3 Receptor:6.0 nM (Ki) Dog H3 Receptor:5.7 nM (Ki) References [1]. Santora VJ, et al. A new family of H3 receptor antagonists based on the natural product Conessine. Bioorg Med Chem Lett. 2008;18(4):1490-1494. [2]. Kim H, et al. Conessine treatment reduces dexamethasone-induced muscle atrophy by regulating MuRF1 and atrogin-1 expression [published online ahead of print, 2018 Feb 1]. J Microbiol Biotechnol. 2018;10.4014.jmb.1711.11009. Chemical & Physical Properties Molecular Formula C24H40N2 Exact Mass 356.319153 PSA 6.48000 Index of Refraction 1.564 InChIKey GPLGAQQQNWMVMM-MYAJQUOBSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
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