CAS Number80-75-1
Synonyms11alpha-hydroxyprogesterone; HYDROXYPROGESTERONE,11A; DG 322B; 11A-HYDROXYPROGESTERONE; EINECS 201-306-9; 4-PREGNEN-11A-OL-3,20-DIONE; MFCD00003652; Progesterone,11alpha-hydroxy; U 0384
Molecular FormulaC21H30O3
Molecular Weight330.46
Purity98.00%
Density1.15 g/cm3
Boiling Point487.4ºC at 760 mmHg
Melting Point165-166ºC(lit.)
AppearanceWhite to light beige crystalline powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 80-75-1 |
| Catalog No. | 2A-1166595 |
| Chinese Name | 11α-羟孕酮 |
| Synonyms | 11alpha-hydroxyprogesterone; HYDROXYPROGESTERONE,11A; DG 322B; 11A-HYDROXYPROGESTERONE; EINECS 201-306-9; 4-PREGNEN-11A-OL-3,20-DIONE; MFCD00003652; Progesterone,11alpha-hydroxy; U 0384 |
| Molecular Formula | C21H30O3 |
| Molecular Weight | 330.46 |
| Purity | 98.00 |
| Density | 1.15 g/cm3 |
| Boiling Point | 487.4ºC at 760 mmHg |
| Melting Point | 165-166ºC(lit.) |
| Appearance | White to light beige crystalline powder |
| Storage Condition | This product should be sealed and stored in a cool |
| Application | 11alpha-Hydroxyprogesterone is an inactive analog of 11beta-Hydroxyprogesterone (HY-N2337) and can be used as a control compound in experiments. 11beta-Hydroxyprogesterone is a potent inhibitor of 11β |
| PubChem ID | 855849 |
| SMILES | CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC12C |
| InChI | InChI=1S/C21H30O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h10,15-19,24H,4-9,11H2,1-3H3/t15-,16?,17-,18+,19+,20-,21+/m0/s1 |
| InChI Key | BFZHCUBIASXHPK-QJSKAATBSA-N |
| Hazard Symbols | transportation |
| Bioactivity | 11alpha-Hydroxyprogesterone is the inactive analogue of 11beta-Hydroxyprogesterone (HY-N2337), and can be used as an experimental control. 11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED50 of 10 nM. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others References [1]. Rafestin-Oblin ME, et al. 11beta-hydroxyprogesterone acts as a mineralocorticoid agonist in stimulating Na+ absorption in mammalian principal cortical collecting duct cells. Mol Pharmacol. 2002 Dec;62(6):1306-13. [2]. Souness GW, et al. 11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid dehydrogenase, possess hypertensinogenic activity in the rat. Hypertension. 1996 Mar;27(3 Pt 1):421-5. Chemical & Physical Properties Density 1.15 g/cm3 Boiling Point 487.4ºC at 760 mmHg Melting Point 165-166ºC(lit.) Molecular Formula C21H30O3 Molecular Weight 330.46 Flash Point 262.7ºC Exact Mass 330.21900 PSA 54.37000 LogP 3.69430 Index of Refraction 1.557 InChIKey BFZHCUBIASXHPK-QJSKAATBSA-N SMILES CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC12C Storage condition Refrigerator |
| Use of | Properties Name 11α-hydroxyprogesterone Synonym More Synonyms Biological Activity Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others References [1]. Rafestin-Oblin ME, et al. 11beta-hydroxyprogesterone acts as a mineralocorticoid agonist in stimulating Na+ absorption in mammalian principal cortical collecting duct cells. Mol Pharmacol. 2002 Dec;62(6):1306-13. [2]. Souness GW, et al. 11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid dehydrogenase, possess hypertensinogenic activity in the rat. Hypertension. 1996 Mar;27(3 Pt 1):421-5. Chemical & Physical Properties Molecular Formula C21H30O3 Exact Mass 330.21900 PSA 54.37000 LogP 3.69430 Index of Refraction 1.557 InChIKey BFZHCUBIASXHPK-QJSKAATBSA-N Storage condition Refrigerator |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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