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DICYCLOMINE HYDROCHLORIDE structure, CAS 67-92-5

DICYCLOMINE HYDROCHLORIDE

CAS Number67-92-5

Synonyms2-(diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate,hydrochloride; Dicyclomine, Hydrochloride

Molecular FormulaC19H36ClNO2

Molecular Weight345.94800

Purity98.00%

Density

Boiling Point399.8ºC at 760 mmHg

Melting Point164-166ºC

Flash Point

Appearancepowder | off-white

EINECS

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Cat. No.: 2A-1166560 Purity: 98.00%
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Quality Control of [ 67-92-5 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number67-92-5
Catalog No.2A-1166560
Chinese Name盐酸双环维林
Synonyms2-(diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate,hydrochloride; Dicyclomine, Hydrochloride
Molecular FormulaC19H36ClNO2
Molecular Weight345.94800
Purity98.00
Boiling Point399.8ºC at 760 mmHg
Melting Point164-166ºC
Appearancepowder | off-white
Water SolubilityH2O: 50 mg/mL
Storage ConditionVentilated and low temperature drying
ApplicationDicyclomine hydrochloride is a potent orally active antagonist of muscarinic cholinergic receptors. Dicyclomine hydrochloride exhibits high affinity for both the M1 receptor subtype (Ki=5.1 nM) and th
SMILESCCN(CC)CCOC(=O)C1(C2CCCCC2)CCCCC1.Cl
InChIInChI=1S/C19H35NO2.ClH/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17;/h17H,3-16H2,1-2H3;1H
InChI KeyGUBNMFJOJGDCEL-UHFFFAOYSA-N
Hazard Symbolstransportation
MSDSmsds/166562_2_67_92_5.pdf
BioactivityDicyclomine hydrochloride is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine hydrochloride shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively[1]. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo[2]. Related Catalog Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease Target Ki: 5.1 nM (muscarinic M1 receptor subtype in brush-border membrane) Ki: 54.6 nM (muscarinic M2 receptor subtype in basal plasma membrane[1] In Vivo Dicyclomine hydrochloride (intraperitoneal injection; 8 mg/kg; daily) exacerbates the cognitive impairments in all the measurements. In addition, the memory impairments are worse in dicyclomine-treated 3xTg-AD mice compared to dicyclomine-treated NonTg mice[2]. Dicyclomine hydrochloride (intraperitoneal injection; 2.0, 4.0, and 8.0 mg/kg; 7 days) produces a highly significant effect on performance in the paired-associates learning (PAL) task in mice.And systemic treatment at lower doses show behavioral impairments in mice in spatial tasks[3]. Animal Model: C57Bl/6 mice[1] Dosage: 2.0, 4.0, and 8.0 mg/kg Administration: Intraperitoneal injection; daily; 7 days Result: Produced impairments due to actions of the agent outside of the hippocampus. References [1]. J Pavía,et al. Pharmacological Characterization and Distribution of Muscarinic Receptors in Human Placental Syncytiotrophoblast Brush-Border and Basal Plasma Membranes. Eur J Pharmacol. . 1997 Feb 12;320(2-3):209-14. [2]. Antonella Caccamo, et al. M1 Receptors Play a Central Role in Modulating AD-like Pathology in Transgenic Mice. 2006 Mar 2;49(5):671-82.doi: 10.1016/j.neuron.2006.01.020. [3]. Susan J Bartko,et al. A Computer-Automated Touchscreen Paired-Associates Learning (PAL) Task for Mice: Impairments Following Administration of Scopolamine or Dicyclomine and Improvements Following Donepezil.Psychopharmacology (Berl). 2011 Mar;214(2):537-48. Chemical & Physical Properties Boiling Point 399.8ºC at 760 mmHg Melting Point 164-166ºC Molecular Formula C19H36ClNO2 Molecular Weight 345.94800 Flash Point 116.5ºC Exact Mass 345.24300 PSA 29.54000 LogP 5.20420 Appearance of Characters powder | off-white InChIKey GUBNMFJOJGDCEL-UHFFFAOYSA-N SMILES CCN(CC)CCOC(=O)C1(C2CCCCC2)CCCCC1.Cl Water Solubility H2O: 50 mg/mL
Use ofDicyclomine hydrochloride is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine hydrochloride shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively[1]. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo[2]. Properties Name dicyclomine hydrochloride Synonym More Synonyms Dicyclomine hydrochloride Biological Activity Description Dicyclomine hydrochloride is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine hydrochloride shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively[1]. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo[2]. Related Catalog Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease Ki: 5.1 nM (muscarinic M1 receptor subtype in brush-border membrane) Ki: 54.6 nM (muscarinic M2 receptor subtype in basal plasma membrane[1] References [1]. J Pavía,et al. Pharmacological Characterization and Distribution of Muscarinic Receptors in Human Placental Syncytiotrophoblast Brush-Border and Basal Plasma Membranes. Eur J Pharmacol. . 1997 Feb 12;320(2-3):209-14. [3]. Susan J Bartko,et al. A Computer-Automated Touchscreen Paired-Associates Learning (PAL) Task for Mice: Impairments Following Administration of Scopolamine or Dicyclomine and Improvements Following Donepezil.Psychopharmacology (Berl). 2011 Mar;214(2):537-48. Chemical & Physical Properties Exact Mass 345.24300 PSA 29.54000 LogP 5.20420 Appearance of Characters powder | off-white InChIKey GUBNMFJOJGDCEL-UHFFFAOYSA-N
Transport InfoProduct name: Purity: 99.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available
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