CAS Number191282-48-1
SynonymsC 75,(2R*,3S*)-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylicacid; 4-Methylene-2-octyl-5-oxotetrahydro-3-furancarboxylic acid; 4-Methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylic acid; 4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid; C75
Molecular FormulaC14H22O4
Molecular Weight254.322
Purity96+%
Density1.1±0.1 g/cm3
Boiling Point432.1±45.0 °C at 760 mmHg
AppearanceWhite to off-white solid
EINECS0
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 191282-48-1 |
| Catalog No. | 2A-0166219 |
| Chinese Name | C75反式 |
| Synonyms | C 75,(2R*,3S*)-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylicacid; 4-Methylene-2-octyl-5-oxotetrahydro-3-furancarboxylic acid; 4-Methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylic acid; 4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid; C75 |
| Molecular Formula | C14H22O4 |
| Molecular Weight | 254.322 |
| Purity | 96+ |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 432.1±45.0 °C at 760 mmHg |
| Appearance | White to off-white solid |
| Storage Condition | Sealed in a cool, dry environment at 2-8 ºC |
| Application | C75 trans is the trans form of C75, which is an effective inhibitor of fatty acid synthase FASN. |
| EINECS | 0 |
| HTC | 2932190090 |
| UN(IATA) | 0 |
| PubChem ID | 14847821 |
| SMILES | C=C1C(=O)OC(CCCCCCCC)C1C(=O)O |
| InChI | InChI=1S/C14H22O4/c1-3-4-5-6-7-8-9-11-12(13(15)16)10(2)14(17)18-11/h11-12H,2-9H2,1H3,(H,15,16)/t11-,12+/m1/s1 |
| InChI Key | VCWLZDVWHQVAJU-NEPJUHHUSA-N |
| Use of | Properties Name trans-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic Acid Synonym More Synonyms trans-C75 Biological Activity Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Fatty Acid Synthase (FAS) Research Areas >> Cancer References [1]. Rae C, et al. Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy. [2]. Makowski K, et al. Differential pharmacologic properties of the two C75 enantiomers: (+)-C75 is a strong anorectic drug; (-)-C75 has antitumor activity. Chirality. 2013 May;25(5):281-7. [3]. Gao S, et al. Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5628-33. [4]. Thupari JN, et al. C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9498-502. Chemical & Physical Properties Molecular Formula C14H22O4 Exact Mass 254.151810 PSA 63.60000 Index of Refraction 1.489 InChIKey VCWLZDVWHQVAJU-NEPJUHHUSA-N Storage condition 2-8℃ Safety Information HS Code 2932190090 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |
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