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TERT-BUTYL (2-(2,5-DIOXO-2,5-DIHYDRO-1H-PYRROL-1-YL)ETHYL)CARBAMATE

Name: TERT-BUTYL (2-(2,5-DIOXO-2,5-DIHYDRO-1H-PYRROL-1-YL)ETHYL)CARBAMATE
Brand: 2A Biotech
SKU: 2A-0164375

CAS Number134272-63-2

Synonyms[2-(2,5-DIOXO-2,5-DIHYDRO-PYRROL-1-YL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER; N-(2-((tert-butoxycarbonyl)amino)ethyl)-maleimide; N-(tert.-butyloxycarbonyl)-2-(N-maleinimido)ethylamine; N-Boc-2-Maleimidoethylamine; tert-Butyl (2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)carbamate; N-BOC-2-malemidoethylamine; 1-((N-tert-butoxycarbonyl)-2-aminoethyl)maleimide; N-[2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl]-carbamic acid tert-butyl ester; 2-(maleimido)ethylcarbamic acid tert-butyl ester; N-(2-[(Boc)amino]ethyl)maleimide

Molecular FormulaC11H16N2O4

Molecular Weight240.25600

Purity96+%

Melting Point110-115 °C

AppearanceWhite to yellow solid

EINECS0

MSDSChinese English

Cat. No.: 2A-0164375 Purity: 96+%

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Quality Control of [ 134272-63-2 ] Purity: 96+% SDS Specification MoL

Chemical & Physical Properties
CAS Number	134272-63-2
Catalog No.	2A-0164375
Chinese Name	N-BOC-2-氨乙基马来酰亚胺
Synonyms	[2-(2,5-DIOXO-2,5-DIHYDRO-PYRROL-1-YL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER; N-(2-((tert-butoxycarbonyl)amino)ethyl)-maleimide; N-(tert.-butyloxycarbonyl)-2-(N-maleinimido)ethylamine; N-Boc-2-Maleimidoethylamine; tert-Butyl (2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)carbamate; N-BOC-2-malemidoethylamine; 1-((N-tert-butoxycarbonyl)-2-aminoethyl)maleimide; N-[2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl]-carbamic acid tert-butyl ester; 2-(maleimido)ethylcarbamic acid tert-butyl ester; N-(2-[(Boc)amino]ethyl)maleimide
Molecular Formula	C11H16N2O4
Molecular Weight	240.25600
Purity	96+
Melting Point	110-115 °C
Appearance	White to yellow solid
Storage Condition	2-8°C, dry, sealed
Application	Mal-NH-Boc is a PROTAC linker, belonging to the alkyl/ether class. Can be used to synthesize PROTAC molecules.
EINECS	0
HTC	2925190090
UN(IATA)	0
PubChem ID	6124490
SMILES	CC(C)(C)OC(=O)NCCN1C(=O)C=CC1=O
InChI	InChI=1S/C11H16N2O4/c1-11(2,3)17-10(16)12-6-7-13-8(14)4-5-9(13)15/h4-5H,6-7H2,1-3H3,(H,12,16)
InChI Key	SNYRFQCLCLMCCG-UHFFFAOYSA-N
MSDS	msds/164375_1_134272_63_2.pdf
Use of	Mal-NH-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Properties Name tert-butyl N-[2-(2,5-dioxopyrrol-1-yl)ethyl]carbamate Synonym More Synonyms Mal-NH-Boc Biological Activity Description Mal-NH-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Alkyl/ether In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 Chemical & Physical Properties Molecular Formula C11H16N2O4 Exact Mass 240.11100 PSA 75.71000 LogP 0.76490 InChIKey SNYRFQCLCLMCCG-UHFFFAOYSA-N Safety Information Hazard Codes Xi HS Code 2925190090 Synthetic Route Maleic anhydride CAS#:108-31-6 N-Boc-Ethylened... CAS#:57260-73-8 Mal-NH-Boc CAS#:134272-63-2 Literature: Richter, Martin; Chakrabarti, Alokta; Ruttekolk, Ivo R.; Wiesner, Burkhard; Beyermann, Michael; Brock, Roland; Rademann, Joerg Chemistry - A European Journal, 2012 , vol. 18, # 52 p. 16708 - 16715 METHYL 2,5-DIOX... CAS#:55750-48-6 Mal-NH-Boc CAS#:134272-63-2 Literature: US5180816 A1, ; Di-tert-butyl d... CAS#:24424-99-5 Mal-NH-Boc CAS#:134272-63-2 Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 21 p. 2843 - 2848 Precursor & DownStream Precursor 7 CAS#:541-59-3 CAS#:26690-80-2 Boc-NH-PEG1-OH CAS#:55750-49-7 Ethyl 2,5-Dioxo... CAS#:57260-73-8 N-Boc-Ethylened... DownStream 1 CAS#:125923-10-6 N-(2-Aminoethyl...
Tax Rebate	9.0%
Supervision	None MFN tariff: 6.5% Ordinary tariff: 30.0%
Transport Info	Product name: Summary 2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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TERT-BUTYL (2-(2,5-DIOXO-2,5-DIHYDRO-1H-PYRROL-1-YL)ETHYL)CARBAMATE

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