CAS Number125414-41-7
Synonymstert-butyl N-(1,3-dihydroxypropan-2-yl)carbamate; 2-Methyl-2-propanyl (1,3-dihydroxy-2-propanyl)carbamate; Carbamic acid, N-[2-hydroxy-1-(hydroxymethyl)ethyl]-, 1,1-dimethylethyl ester; 1,1-Dimethylethyl [2-hydroxy-1-(hydroxymethyl)ethyl]carbamate
Molecular FormulaC8H17NO4
Molecular Weight191.22
Purity97%
Density1.1±0.1 g/cm3
Boiling Point363.0±32.0 °C at 760 mmHg
Melting Point85-89 °C
Appearancesolid
EINECS0
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 125414-41-7 |
| Catalog No. | 2A-0164309 |
| Chinese Name | N-Boc-丝氨醇 |
| Synonyms | tert-butyl N-(1,3-dihydroxypropan-2-yl)carbamate; 2-Methyl-2-propanyl (1,3-dihydroxy-2-propanyl)carbamate; Carbamic acid, N-[2-hydroxy-1-(hydroxymethyl)ethyl]-, 1,1-dimethylethyl ester; 1,1-Dimethylethyl [2-hydroxy-1-(hydroxymethyl)ethyl]carbamate |
| Molecular Formula | C8H17NO4 |
| Molecular Weight | 191.22 |
| Purity | 97 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 363.0±32.0 °C at 760 mmHg |
| Melting Point | 85-89 °C |
| Appearance | solid |
| Storage Condition | Room temperature, protected from light, dry and se |
| Application | N-Boc-serinol is a PROTAC linker, belonging to the alkyl/ether class. Can be used to synthesize PROTAC molecules. |
| EINECS | 0 |
| HTC | 2924199090 |
| UN(IATA) | 0 |
| PubChem ID | 24884499 |
| MDL Number | MFCD00270213 |
| SMILES | CC(C)(C)OC(=O)NC(CO)CO |
| InChI | 1S/C8H17NO4/c1-8(2,3)13-7(12)9-6(4-10)5-11/h6,10-11H,4-5H2,1-3H3,(H,9,12) |
| InChI Key | JHBKBRLRYPYBLP-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | transportation |
| MSDS | msds/164309_1_125414_41_7.pdf |
| Bioactivity | N-Boc-serinol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Target Alkyl/ether In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 363.0±32.0 °C at 760 mmHg Melting Point 85-89ºC Molecular Formula C8H17NO4 Molecular Weight 191.225 Flash Point 173.4±25.1 °C Exact Mass 191.115753 PSA 78.79000 LogP 0.30 Vapour Pressure 0.0±1.8 mmHg at 25°C Index of Refraction 1.476 InChIKey JHBKBRLRYPYBLP-UHFFFAOYSA-N SMILES CC(C)(C)OC(=O)NC(CO)CO |
| Use of | N-Boc-serinol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Properties Name tert-Butyl (1,3-dihydroxypropan-2-yl)carbamate Synonym More Synonyms N-Boc-serinol Biological Activity Description N-Boc-serinol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Alkyl/ether In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 Chemical & Physical Properties Molecular Formula C8H17NO4 Exact Mass 191.115753 PSA 78.79000 Index of Refraction 1.476 InChIKey JHBKBRLRYPYBLP-UHFFFAOYSA-N SMILES CC(C)(C)OC(=O)NC(CO)CO |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 0.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available |
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