CAS Number154235-83-3
Synonymspiperidin-1-yl(quinoxalin-6-yl)methanone; 1-Piperidinyl(6-quinoxalinyl)methanone; 1-(quinoxalin-6-ylcarbonyl)piperidine; Ampalex; BDP-12
Molecular FormulaC14H15N3O
Molecular Weight241.29
Purity≥98 (HPLC)%
Density1.2±0.1 g/cm3
Boiling Point433.1±25.0 °C at 760 mmHg
Melting Point88-90ºC
Appearancepowder
EINECS0
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 154235-83-3 |
| Catalog No. | 2A-0163524 |
| Chinese Name | 安帕来斯 |
| Synonyms | piperidin-1-yl(quinoxalin-6-yl)methanone; 1-Piperidinyl(6-quinoxalinyl)methanone; 1-(quinoxalin-6-ylcarbonyl)piperidine; Ampalex; BDP-12 |
| Molecular Formula | C14H15N3O |
| Molecular Weight | 241.29 |
| Purity | ≥98 (HPLC) |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 433.1±25.0 °C at 760 mmHg |
| Melting Point | 88-90ºC |
| Appearance | powder |
| Storage Condition | 2~8℃ |
| Application | Ampalex (Ampakine CX516; CX516; BDP 12) is a positive allosteric modulator of AMPA receptors and can act on Alzheimer's disease, schizophrenia, etc. |
| EINECS | 0 |
| HTC | 2933990090 |
| UN(IATA) | 0 |
| PubChem ID | 329825710 |
| MDL Number | MFCD00943201 |
| SMILES | O=C(C1=CC2=NC=CN=C2C=C1)N3CCCCC3 |
| InChI | 1S/C14H15N3O/c18-14(17-8-2-1-3-9-17)11-4-5-12-13(10-11)16-7-6-15-12/h4-7,10H,1-3,8-9H2 |
| InChI Key | ANDGGVOPIJEHOF-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/163524_1_154235_83_3.pdf |
| Use of | Ampalex (Ampakine CX516; CX516; BDP 12) is an ampakine and nootropic that acts as an AMPA receptor positive allosteric modulator as a treatment for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI). IC50 value: Target: AMPA receptorAmpalex ameliorates functional deficits in AMPA receptors in a hippocampal slice model of protein accumulation. Researches suggest that AMPA receptors may be potential pharmaceutical targets for the treatment of neurodegenerative diseases, and highlights AMPAkines, in particular, as possible therapeutic agents. Properties Name Piperidin-1-yl(quinoxalin-6-yl)methanone Synonym More Synonyms Ampalex Biological Activity Description Ampalex (Ampakine CX516; CX516; BDP 12) is an ampakine and nootropic that acts as an AMPA receptor positive allosteric modulator as a treatment for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI). IC50 value: Target: AMPA receptorAmpalex ameliorates functional deficits in AMPA receptors in a hippocampal slice model of protein accumulation. Researches suggest that AMPA receptors may be potential pharmaceutical targets for the treatment of neurodegenerative diseases, and highlights AMPAkines, in particular, as possible therapeutic agents. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease References [1]. Broberg BV, Glenth?j BY, Dias R, et al. Reversal of cognitive deficits by an ampakine (CX516) and sertindole in two animal models of schizophrenia--sub-chronic and early postnatal PCP treatment in attentional set-shifting. Psychopharmacology (Berl). 2009 [2]. Kanju PM, Parameshwaran K, Sims C, et al. Ampakine CX516 ameliorates functional deficits in AMPA receptors in a hippocampal slice model of protein accumulation. Exp Neurol. 2008 Nov;214(1):55-61. [3]. Goff DC, Lamberti JS, Leon AC, et al. A placebo-controlled add-on trial of the Ampakine, CX516, for cognitive deficits in schizophrenia. Neuropsychopharmacology. 2008 Feb;33(3):465-72. [4]. O'Neill MJ, Witkin JM. AMPA receptor potentiators: application for depression and Parkinson's disease. Curr Drug Targets. 2007 May;8(5):603-20. [5]. Johnson SA, Simmon VF. Randomized, double-blind, placebo-controlled international clinical trial of the Ampakine CX516 in elderly participants with mild cognitive impairment: a progress report. J Mol Neurosci. 2002 Aug-Oct;19(1-2):197-200. Chemical & Physical Properties Molecular Formula C14H15N3O Exact Mass 241.121506 PSA 46.09000 Index of Refraction 1.640 InChIKey ANDGGVOPIJEHOF-UHFFFAOYSA-N Storage condition 2~8℃ Safety Information Signal Word Warning Hazard Statements H302 Hazard Codes Xi RIDADR NONH for all modes of transport RTECS TM2785170 HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| PIPERAZIN-2-YLMETHANAMINE | 130861-85-7 | 2A-0163500 |
| PIPERIDIN-1-OL | 4801-58-5 | 2A-0163519 |
| PIPERIDIN-1-YL(PIPERIDIN-2-YL)METHANONE HYDROCHLORIDE | 16783-69-0 | 2A-0163521 |
| PIPERIDIN-1-YL(PIPERIDIN-4-YL)METHANONE HYDROCHLORIDE | 278598-12-2 | 2A-0163522 |
| PIPERIDIN-1-YL(PYRROLIDIN-2-YL)METHANONE | 166975-75-3 | 2A-0163523 |
| PIPERIDIN-2-IMINE HYDROCHLORIDE | 16011-96-4 | 2A-0163525 |
| PIPERIDIN-2-YL(PYRROLIDIN-1-YL)METHANONE | 130605-98-0 | 2A-0163526 |
| PIPERIDIN-3-YL-PYRROLIDIN-1-YL-METHANONE HYDROCHLORIDE | 937724-81-7 | 2A-0163552 |
| PIPERIDIN-3-YLMETHANAMINE DIHYDROCHLORIDE | 71766-76-2 | 2A-0163554 |
| PIPERIDIN-4-YL ACETATE HYDROCHLORIDE | 94886-04-1 | 2A-0163586 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS