CAS Number165668-41-7
SynonymsE7070; Indisulam (IND); indisulam; N-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide; N-(3-Chloro-1H-indol-7-yl)benzene-1,4-disulfonamide; Indisulam (USAN/INN); 1,4-Benzenedisulfonamide,N-(3-chloro-1H-indol-7-yl)
Molecular FormulaC14H12ClN3O4S2
Molecular Weight385.85
Purity≥98 (HPLC)%
Density1.7±0.1 g/cm3
Boiling Point668.9±65.0 °C at 760 mmHg
Appearancepowder
EINECS0
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 165668-41-7 |
| Catalog No. | 2A-0162966 |
| Chinese Name | N-(3-氯-1H-吲哚-7-基)-1,4-苯二磺酰胺 |
| Synonyms | E7070; Indisulam (IND); indisulam; N-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide; N-(3-Chloro-1H-indol-7-yl)benzene-1,4-disulfonamide; Indisulam (USAN/INN); 1,4-Benzenedisulfonamide,N-(3-chloro-1H-indol-7-yl) |
| Molecular Formula | C14H12ClN3O4S2 |
| Molecular Weight | 385.85 |
| Purity | ≥98 (HPLC) |
| Density | 1.7±0.1 g/cm3 |
| Boiling Point | 668.9±65.0 °C at 760 mmHg |
| Appearance | powder |
| Storage Condition | 2-8℃ |
| Application | Indisulam (E 7070) is a carbonic anhydrase inhibitor and a compound targeting the G1 phase of the cell cycle. By inhibiting the activation of cyclin-dependent kinase 2 (CDK2) and cyclin E, the G1/S tr |
| EINECS | 0 |
| HTC | 2935009090 |
| UN(IATA) | 0 |
| PubChem ID | 329825730 |
| MDL Number | MFCD00945325 |
| SMILES | ClC1=CNC2=C1C=CC=C2NS(C3=CC=C(S(=O)(N)=O)C=C3)(=O)=O |
| InChI | 1S/C14H12ClN3O4S2/c15-12-8-17-14-11(12)2-1-3-13(14)18-24(21,22)10-6-4-9(5-7-10)23(16,19)20/h1-8,17-18H,(H2,16,19,20) |
| InChI Key | SETFNECMODOHTO-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/162966_1_165668_41_7.pdf |
| Use of | Properties Name 4-N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide Synonym More Synonyms Indisulam Biological Activity Related Catalog Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase Carbonic anhydrase[1]. References [1]. Ozawa Y, et al. E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivo. Eur J Cancer. 2001 Nov;37(17):2275-82. [2]. Abbate F, et al. Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Bioorg Med Chem Lett. 2004 Jan 5;14(1):217-23. Chemical & Physical Properties Exact Mass 384.995789 PSA 138.88000 Index of Refraction 1.731 InChIKey SETFNECMODOHTO-UHFFFAOYSA-N Storage condition 2-8℃ Safety Information Signal Word Warning Hazard Statements H315-H319 Precautionary Statements P305 + P351 + P338 RIDADR NONH for all modes of transport HS Code 2935009090 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 35.0% |
| Transport Info | Product name: Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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