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N-CYCLOHEXYL-2-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)-6-METHYLPYRIMIDIN-4-AMINE

Name: N-CYCLOHEXYL-2-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)-6-METHYLPYRIMIDIN-4-AMINE
Brand: 2A Biotech
SKU: 2A-0162264

CAS Number73029-73-9

SynonymsSynthalin sulfate; CyPPA; N-Cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methyl-4-pyrimidinamine; N-cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-amine

Molecular FormulaC16H23N5

Molecular Weight285.39

Purity≥98 (HPLC)%

Density1.2±0.1 g/cm3

Boiling Point512.2±42.0 °C at 760 mmHg

Appearancesolid

EINECS0

MSDSChinese English

Symbol

Signal WordWarning

Cat. No.: 2A-0162264 Purity: ≥98 (HPLC)%

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Quality Control of [ 73029-73-9 ] Purity: ≥98 (HPLC)% SDS Specification MoL

Chemical & Physical Properties
CAS Number	73029-73-9
Catalog No.	2A-0162264
Chinese Name	N-环己基-N-[2-(3,5-二甲基吡唑-1-基)-6-甲基嘧啶-4-基]胺
Synonyms	Synthalin sulfate; CyPPA; N-Cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methyl-4-pyrimidinamine; N-cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-amine
Molecular Formula	C16H23N5
Molecular Weight	285.39
Purity	≥98 (HPLC)
Density	1.2±0.1 g/cm3
Boiling Point	512.2±42.0 °C at 760 mmHg
Appearance	solid
Storage Condition	2-8℃
Application	CyPPA is a positive modulator of hSK3 and hSK2 with EC50 values of 14 μM and 5.6 μM, respectively. CyPPA is inactive against hSK1 and hIK channels.
EINECS	0
HTC	2933990090
UN(IATA)	0
PubChem ID	329775087
MDL Number	MFCD01550586
SMILES	Cc1cc(NC2CCCCC2)nc(n1)-n3nc(C)cc3C
InChI	1S/C16H23N5/c1-11-10-15(18-14-7-5-4-6-8-14)19-16(17-11)21-13(3)9-12(2)20-21/h9-10,14H,4-8H2,1-3H3,(H,17,18,19)
InChI Key	USEMRPYUFJNFQN-UHFFFAOYSA-N
NACRES Code	NA.77
UNSPSC	12352200
Hazard Symbols	transportation
MSDS	msds/162264_1_73029_73_9.pdf
Bioactivity	CyPPA is a positive modulator of hSK3 and hSK2, with EC50 values of 14 μM and 5.6 μM, repectively. CyPPA is inactive on both hSK1 and hIK channels[1][2]. Related Catalog Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel In Vitro CyPPA induces a concentration-dependent increase in the apparent Ca2+-sensitivity of channel activation, changing the EC50 (Ca2+) from 429 nM to 59 nM[1]. In Vivo CyPPA, a positive modulator of small-conductance Ca2+-activated K+ channels, inhibits phasic uterine contractions and delays preterm birth in mice[2]. References [1]. Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate. Br J Pharmacol. 2007 Jul;151(5):655-65. [2]. Dana V Skarra, et al. CyPPA, a positive modulator of small-conductance Ca(2+)-activated K(+) channels, inhibits phasic uterine contractions and delays preterm birth in mice. Am J Physiol Cell Physiol. 2011 Nov;301(5):C1027-35. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 512.2±42.0 °C at 760 mmHg Molecular Formula C16H23N5 Molecular Weight 285.387 Flash Point 263.6±27.9 °C Exact Mass 285.195343 PSA 55.63000 LogP 2.13 Vapour Pressure 0.0±1.3 mmHg at 25°C Index of Refraction 1.648 InChIKey USEMRPYUFJNFQN-UHFFFAOYSA-N SMILES Cc1cc(NC2CCCCC2)nc(-n2nc(C)cc2C)n1 Storage condition 2-8℃
Use of	CyPPA is a positive modulator of hSK3 and hSK2, with EC50 values of 14 μM and 5.6 μM, repectively. CyPPA is inactive on both hSK1 and hIK channels[1][2]. Properties Name N-cyclohexyl-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine Synonym More Synonyms CyPPA Biological Activity Description CyPPA is a positive modulator of hSK3 and hSK2, with EC50 values of 14 μM and 5.6 μM, repectively. CyPPA is inactive on both hSK1 and hIK channels[1][2]. Related Catalog Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel In Vitro CyPPA induces a concentration-dependent increase in the apparent Ca2+-sensitivity of channel activation, changing the EC50 (Ca2+) from 429 nM to 59 nM[1]. In Vivo CyPPA, a positive modulator of small-conductance Ca2+-activated K+ channels, inhibits phasic uterine contractions and delays preterm birth in mice[2]. References [1]. Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate. Br J Pharmacol. 2007 Jul;151(5):655-65. [2]. Dana V Skarra, et al. CyPPA, a positive modulator of small-conductance Ca(2+)-activated K(+) channels, inhibits phasic uterine contractions and delays preterm birth in mice. Am J Physiol Cell Physiol. 2011 Nov;301(5):C1027-35. Chemical & Physical Properties Molecular Formula C16H23N5 Exact Mass 285.195343 PSA 55.63000 Index of Refraction 1.648 InChIKey USEMRPYUFJNFQN-UHFFFAOYSA-N Storage condition 2-8℃
Tax Rebate	13.0%
Supervision	None. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport Info	Product name: Purity: 98.0%
MSDS Transport Info	Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available The above information is believed to be correct, but is not all-inclusive and should be used as a guide only. The information in this document is based on our current knowledge and is Correct safety instructions apply to this product. This information does not represent a warranty as to the properties of this product. See reverse side of invoice or packing slip.

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N-CYCLOHEXYL-2-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)-6-METHYLPYRIMIDIN-4-AMINE

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