CAS Number142253-55-2
Synonyms1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-3-azetidinecarboxylic acid; 1-N-Boc-3-Azetidinecarboxylic Acid; 1-[(2-methylpropan-2-yl)oxycarbonyl]azetidine-3-carboxylic acid; MFCD01860897; 1-(tert-Butoxycarbonyl)azetidine-3-carboxylic Acid; N-Boc-Azetidine-3-carboxylic acid; 1-BOC-Azetidine-3-carboxylic acid; 1-Boc-azetidine-3-carboxylicacid
Molecular FormulaC9H15NO4
Molecular Weight241.28
Purity97%
Density1.2±0.1 g/cm3
Boiling Point321.0±35.0 °C at 760 mmHg
Melting Point147-152 °C
Appearancepowder
EINECS0
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 142253-55-2 |
| Catalog No. | 2A-0162145 |
| Chinese Name | 1-Boc-氮杂环丁烷-3-羧酸 |
| Synonyms | 1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-3-azetidinecarboxylic acid; 1-N-Boc-3-Azetidinecarboxylic Acid; 1-[(2-methylpropan-2-yl)oxycarbonyl]azetidine-3-carboxylic acid; MFCD01860897; 1-(tert-Butoxycarbonyl)azetidine-3-carboxylic Acid; N-Boc-Azetidine-3-carboxylic acid; 1-BOC-Azetidine-3-carboxylic acid; 1-Boc-azetidine-3-carboxylicacid |
| Molecular Formula | C9H15NO4 |
| Molecular Weight | 241.28 |
| Purity | 97 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 321.0±35.0 °C at 760 mmHg |
| Melting Point | 147-152 °C |
| Appearance | powder |
| Storage Condition | Seal and store at -15ºC |
| Application | 1-Boc-azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Boc-azetidine-3-carboxylic acid is also an alkyl chain-based PROTAC linker a |
| EINECS | 0 |
| HTC | 2933990090 |
| UN(IATA) | 0 |
| PubChem ID | 329761746 |
| MDL Number | MFCD11099876 |
| SMILES | CC(C)(C)OC(=O)N1C2CCC(C2)[C@H]1C(O)=O |
| InChI | 1S/C12H19NO4/c1-12(2,3)17-11(16)13-8-5-4-7(6-8)9(13)10(14)15/h7-9H,4-6H2,1-3H3,(H,14,15)/t7-,8+,9-/m0/s1 |
| InChI Key | IFAMSTPTNRJBRG-YIZRAAEISA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352005 |
| Hazard Symbols | transportation |
| MSDS | msds/162145_1_142253_55_2.pdf |
| Bioactivity | 1-Boc-azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Boc-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2] Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Target Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 321.0±35.0 °C at 760 mmHg Melting Point 100.1-101.9°C Molecular Formula C9H15NO4 Molecular Weight 201.220 Flash Point 147.9±25.9 °C Exact Mass 201.100113 PSA 66.84000 LogP 0.27 Vapour Pressure 0.0±1.5 mmHg at 25°C Index of Refraction 1.510 InChIKey NCADHSLPNSTDMJ-UHFFFAOYSA-N SMILES CC(C)(C)OC(=O)N1CC(C(=O)O)C1 Storage condition Store at -15°C |
| Use of | 1-Boc-azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Boc-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2] Properties Name 1-Boc-3-Azetidine-3-carboxylic acid Synonym More Synonyms 1-Boc-azetidine-3-carboxylic acid Biological Activity Description 1-Boc-azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Boc-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2] Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Molecular Formula C9H15NO4 Exact Mass 201.100113 PSA 66.84000 Index of Refraction 1.510 InChIKey NCADHSLPNSTDMJ-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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