CAS Number1124-11-4
SynonymsMFCD00006146; Chuanxingzine; Ligustrazine; 2,3,5,6-Tetramethylpyrazine; EINECS 214-391-2; 2,3,5,6,-Tetramethyl-1,4-pyrazine; Tetramethyl-1,4-diazine; Tetramethylpyrazine; 2,3,5,6-TETRA METHYL PYRAZINE
Molecular FormulaC8H12N2
Molecular Weight136.19
Purity≥98%
Density1.0±0.1 g/cm3
Boiling Point190 °C (lit.)
Melting Point77-80 °C (lit.)
Appearancewhite crystal or powder
EINECS214-391-2
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1124-11-4 |
| Catalog No. | 2A-9001620 |
| Chinese Name | 川芎嗪 |
| Synonyms | MFCD00006146; Chuanxingzine; Ligustrazine; 2,3,5,6-Tetramethylpyrazine; EINECS 214-391-2; 2,3,5,6,-Tetramethyl-1,4-pyrazine; Tetramethyl-1,4-diazine; Tetramethylpyrazine; 2,3,5,6-TETRA METHYL PYRAZINE |
| Molecular Formula | C8H12N2 |
| Molecular Weight | 136.19 |
| Purity | ≥98 |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 190 °C (lit.) |
| Melting Point | 77-80 °C (lit.) |
| Appearance | white crystal or powder |
| Storage Condition | Keep the receptacle sealed, stored in a cool, dry |
| Application | Tetramethylpyrazine (Ligustrazine) is an alkylpyrazine extracted from Ligusticum wallichii (Chuan Xiong). It is often used as a flavor in French fries, bread, tea, dairy products, soy products and oth |
| EINECS | 214-391-2 |
| HTC | 29339990 |
| PubChem ID | 24901576 |
| MDL Number | MFCD00006146 |
| SMILES | Cc1nc(C)c(C)nc1C |
| InChI | 1S/C8H12N2/c1-5-6(2)10-8(4)7(3)9-5/h1-4H3 |
| InChI Key | FINHMKGKINIASC-UHFFFAOYSA-N |
| Beilstein/REAXYS | 113100 |
| NACRES Code | NA.21 |
| eCl@ss | 39161809 |
| UNSPSC | 12164502 |
| Hazard Symbols | Transport |
| Risk Codes | R22 |
| Safety Description | S24/25 |
| MSDS | msds/1620_1_1124_11_4.pdf |
| Bioactivity | Tetramethylpyrazine (Ligustrazine), an alkylpyrazine isolated from Ligusticum wallichii (Chuan Xiong)[1], is present in french fries, bread, cooked meats, tea, cocoa, coffee, beer, spirits, peanuts, filberts, dairy products and soy products as fragrance and flavouring ingredienexhibits. Tetramethylpyrazine (Ligustrazine) also has potential nootropic and anti-inflammatory activities in rats[2][3]. Related Catalog Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Research Areas >> Neurological Disease In Vitro Tetramethylpyrazine has been extensively used in China for cardiovascular and cerebrovascular diseases for about 40 years. Because of its effectiveness in multisystem, especially in cardiovascular. Tetramethylpyrazine also has been used in various diseases, such as coronary heart disease, diabetes, cancers, and liver injury[1]. References [1]. Zhao Y, et al. Mechanisms and Clinical Application of Tetramethylpyrazine (an Interesting Natural Compound Isolated from Ligusticum Wallichii): Current Status and Perspective. Oxid Med Cell Longev. 2016;2016:2124638. [2]. Wu W, et al. Tetramethylpyrazine protects against scopolamine-induced memory impairments in rats by reversing the cAMP/PKA/CREB pathway. Behav Brain Res. 2013 Sep 15;253:212-6. [3]. Kao TK, et al. Tetramethylpyrazine reduces cellular inflammatory response following permanent focal cerebral ischemia in rats. Exp Neurol. 2013 Sep;247:188-201. Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 192.7±35.0 °C at 760 mmHg Melting Point 77-80 °C(lit.) Molecular Formula C8H12N2 Molecular Weight 136.19 Flash Point 71.6±17.6 °C Exact Mass 136.100052 PSA 25.78000 LogP 1.56 Vapour Pressure 0.7±0.4 mmHg at 25°C Index of Refraction 1.504 InChIKey FINHMKGKINIASC-UHFFFAOYSA-N SMILES Cc1nc(C)c(C)nc1C Stability Stable. Incompatible with strong acids, strong oxidizing agents. |
| Use of | Tetramethylpyrazine (Ligustrazine), an alkylpyrazine isolated from Ligusticum wallichii (Chuan Xiong)[1], is present in french fries, bread, cooked meats, tea, cocoa, coffee, beer, spirits, peanuts, filberts, dairy products and soy products as fragrance and flavouring ingredienexhibits. Tetramethylpyrazine (Ligustrazine) also has potential nootropic and anti-inflammatory activities in rats[2][3]. Properties Articles36 Name Tetramethylpyrazine Synonym More Synonyms Tetramethylpyrazine Biological Activity Description Tetramethylpyrazine (Ligustrazine), an alkylpyrazine isolated from Ligusticum wallichii (Chuan Xiong)[1], is present in french fries, bread, cooked meats, tea, cocoa, coffee, beer, spirits, peanuts, filberts, dairy products and soy products as fragrance and flavouring ingredienexhibits. Tetramethylpyrazine (Ligustrazine) also has potential nootropic and anti-inflammatory activities in rats[2][3]. Related Catalog Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Research Areas >> Neurological Disease In Vitro Tetramethylpyrazine has been extensively used in China for cardiovascular and cerebrovascular diseases for about 40 years. Because of its effectiveness in multisystem, especially in cardiovascular. Tetramethylpyrazine also has been used in various diseases, such as coronary heart disease, diabetes, cancers, and liver injury[1]. References [1]. Zhao Y, et al. Mechanisms and Clinical Application of Tetramethylpyrazine (an Interesting Natural Compound Isolated from Ligusticum Wallichii): Current Status and Perspective. Oxid Med Cell Longev. 2016;2016:2124638. [2]. Wu W, et al. Tetramethylpyrazine protects against scopolamine-induced memory impairments in rats by reversing the cAMP/PKA/CREB pathway. Behav Brain Res. 2013 Sep 15;253:212-6. [3]. Kao TK, et al. Tetramethylpyrazine reduces cellular inflammatory response following permanent focal cerebral ischemia in rats. Exp Neurol. 2013 Sep;247:188-201. Chemical & Physical Properties Molecular Formula C8H12N2 Exact Mass 136.100052 PSA 25.78000 Index of Refraction 1.504 InChIKey FINHMKGKINIASC-UHFFFAOYSA-N Stability Stable. Incompatible with strong acids, strong oxidizing agents. |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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