CAS Number176644-21-6
SynonymsUNII-7IGF9182QU; Eniporide; N-(diaminomethylidene)-2-methyl-5-(methylsulfonyl)-4-(1H-pyrrol-1-yl)benzamide; N-Carbamimidoyl-2-methyl-5-(methylsulfonyl)-4-(1H-pyrrol-1-yl)benzamide; EMD96785
Molecular FormulaC14H16O3N4S1
Molecular Weight320.37
Purity96+%
Density1.4±0.1 g/cm3
Boiling Point635.9±65.0 °C at 760 mmHg
EINECS0
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 176644-21-6 |
| Catalog No. | 2A-0161616 |
| Chinese Name | N-(二氨基亚甲基)-2-甲基-5-(甲基磺酰基)-4-(1H-吡咯-1-基)苯甲酰胺 |
| Synonyms | UNII-7IGF9182QU; Eniporide; N-(diaminomethylidene)-2-methyl-5-(methylsulfonyl)-4-(1H-pyrrol-1-yl)benzamide; N-Carbamimidoyl-2-methyl-5-(methylsulfonyl)-4-(1H-pyrrol-1-yl)benzamide; EMD96785 |
| Molecular Formula | C14H16O3N4S1 |
| Molecular Weight | 320.37 |
| Purity | 96+ |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 635.9±65.0 °C at 760 mmHg |
| Storage Condition | 2-8°C |
| Application | Eniporide (EMD 96785) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniboli specifically inhibits the NHE-1 isoform. Enipalide improved cardiac function depression associated with myocardial ischemia/repe |
| EINECS | 0 |
| HTC | 2933990090 |
| UN(IATA) | 0 |
| MDL Number | MFCD08690425 |
| SMILES | Cc1cc(-n2cccc2)c(S(C)(=O)=O)cc1C(=O)N=C(N)N |
| InChI | InChI=1S/C14H16N4O3S/c1-9-7-11(18-5-3-4-6-18)12(22(2,20)21)8-10(9)13(19)17-14(15)16/h3-8H,1-2H3,(H4,15,16,17,19) |
| InChI Key | UADMBZFZZOBWBB-UHFFFAOYSA-N |
| MSDS | msds/161616_1_176644_21_6.pdf |
| Use of | Eniporide (EMD 96785) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide specifically inhibits the NHE-1 isoform. Eniporide improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide regulates cardiac performance and high-energy phosphate content in clinically relevant pig models of CPB and cardiac arrest[1][2]. Properties Name N-(diaminomethylidene)-2-methyl-5-methylsulfonyl-4-pyrrol-1-ylbenzamide Synonym More Synonyms Eniporide Biological Activity Description Eniporide (EMD 96785) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide specifically inhibits the NHE-1 isoform. Eniporide improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide regulates cardiac performance and high-energy phosphate content in clinically relevant pig models of CPB and cardiac arrest[1][2]. Related Catalog Research Areas >> Others In Vitro ENIPORIDE is a potent Na+/H+ exchange inhibitor. References [1]. Zeymer U, et al. The Na(+)/H(+) exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction. Results of the evaluation of the safety and cardioprotective effects of eniporide in acute myocardial infarction (ESCAMI) trial. J Am Coll Cardiol. 2001 Nov 15;38(6):1644-50. [2]. Klass O, et al. Effect of the Na+/H+ exchange inhibitor eniporide on cardiac performance and myocardial high energy phosphates in pigs subjected to cardioplegic arrest. Ann Thorac Surg. 2004 Feb;77(2):658-63. Chemical & Physical Properties Molecular Formula C14H16N4O3S Exact Mass 320.094299 PSA 128.92000 Index of Refraction 1.656 InChIKey UADMBZFZZOBWBB-UHFFFAOYSA-N Safety Information Hazard Codes Xi HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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