![N-(6-CHLORO-7-METHOXY-9H-PYRIDO[3,4-B]INDOL-8-YL)-2-METHYLNICOTINAMIDE structure, CAS 783348-36-7](https://www.2abiotech.com/storage/file/20260617/e60459db0b750cc209beb386b67b43889b079997.png)
CAS Number783348-36-7
Synonymscs-1291; ml-120b; mln-120b; N-(6-Chloro-7-methoxy-9H-β-carbolin-8-yl)-2-methylnicotinamide; MLN120B
Molecular FormulaC19H15ClN4O2
Molecular Weight366.80
Purity≥98 (HPLC)%
Density1.4±0.1 g/cm3
Boiling Point545.0±50.0 °C at 760 mmHg
Appearancepowder
EINECS0
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 783348-36-7 |
| Catalog No. | 2A-0161558 |
| Chinese Name | N-(6-氯-7-甲氧基-9h-吡啶并[3,4-b]吲哚-8-基)-2-甲基-3-吡啶羧酰胺 |
| Synonyms | cs-1291; ml-120b; mln-120b; N-(6-Chloro-7-methoxy-9H-β-carbolin-8-yl)-2-methylnicotinamide; MLN120B |
| Molecular Formula | C19H15ClN4O2 |
| Molecular Weight | 366.80 |
| Purity | ≥98 (HPLC) |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 545.0±50.0 °C at 760 mmHg |
| Appearance | powder |
| Storage Condition | 2-8℃ |
| Application | MLN120B is a specific ATP-competitive IKKβ inhibitor with an IC50 of 60 nM. |
| EINECS | 0 |
| HTC | 2933990090 |
| UN(IATA) | 0 |
| PubChem ID | 14901714 |
| SMILES | Clc1cc2c([nH]c4c2ccnc4)c(c1OC)NC(=O)c3c(nccc3)C |
| InChI | 1S/C19H15ClN4O2/c1-10-11(4-3-6-22-10)19(25)24-17-16-13(8-14(20)18(17)26-2)12-5-7-21-9-15(12)23-16/h3-9,23H,1-2H3,(H,24,25) |
| InChI Key | ZNOLRTPMNMPLHY-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/161558_1_783348_36_7.pdf |
| Use of | MLN120B is a specific, ATP competitive IKKβ inhibitor with an IC50 of 60 nM. Properties Name N-(6-chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methylpyridine-3-carboxamide Synonym More Synonyms MLN120B Biological Activity Description MLN120B is a specific, ATP competitive IKKβ inhibitor with an IC50 of 60 nM. Related Catalog Signaling Pathways >> NF-κB >> IKK Research Areas >> Cancer IKKβ:60 nM (IC50) References [1]. Hideshima T, et all. MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo. Clin Cancer Res. 2006 Oct 1;12(19):5887-94. [2]. Schopf L, et al. IKKbeta inhibition protects against bone and cartilage destruction in a rat model of rheumatoid arthritis. Arthritis Rheum. 2006 Oct;54(10):3163-73. [3]. Ansaldi D, et al. Imaging pulmonary NF-kappaB activation and therapeutic effects of MLN120B and TDZD-8. PLoS One. 2011;6(9):e25093. [4]. Nagashima K, et al. Rapid TNFR1-dependent lymphocyte depletion in vivo with a selective chemical inhibitor of IKKbeta. Blood. 2006 Jun 1;107(11):4266-73. Chemical & Physical Properties Exact Mass 366.088348 PSA 83.39000 Index of Refraction 1.752 InChIKey ZNOLRTPMNMPLHY-UHFFFAOYSA-N Storage condition 2-8℃ Safety Information Signal Word Warning Hazard Statements H302 RIDADR NONH for all modes of transport HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Related Products in Heterocyclic Building Blocks | ||
|---|---|---|
| N-(4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL)-2,2-DIMETHYLPROPIONAMIDE | 149765-15-1 | 2A-0161238 |
| N-(4-FLUOROPHENYL)THIOPHENE-2-CARBOXAMIDE | 136340-91-5 | 2A-0161293 |
| N-(4-SULFAMOYLPHENYL)-4-(2-(TRIFLUOROMETHYL)BENZYL)PIPERAZINE-1-CARBOXAMIDE | 1032229-30-3 | 2A-0161366 |
| N-(5-METHYLISOXAZOL-3-YL)ISOCHROMAN-1-CARBOXAMIDE | 838896-06-3 | 2A-0161530 |
| N-(6-((2-METHOXYETHYL)(METHYL)AMINO)PYRIDIN-3-YL)-2-PHENYL-4-(TRIFLUOROMETHYL)OXAZOLE-5-CARBOXAMIDE | 939376-09-7 | 2A-0161538 |
| N-(FURAN-2-YLMETHYL)-1,2-DIPHENYLETHANAMINE | 436087-17-1 | 2A-0161620 |
| N-(FURAN-2-YLMETHYL)-3,4-DIMETHOXYANILINE | 436088-80-1 | 2A-0161621 |
| N-(FURAN-2-YLMETHYL)-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIMIDIN-2-AMINE | 1218790-00-1 | 2A-0161623 |
| N-(FURAN-2-YLMETHYL)ETHANAMINE | 14496-33-4 | 2A-0161624 |
| N-(PIPERIDIN-4-YL)THIOPHENE-3-CARBOXAMIDE HYDROCHLORIDE | 1185314-33-3 | 2A-0161684 |
| Browse all Heterocyclic Building Blocks products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS