![N-(4-(2-ETHYL-1-(1H-1,2,4-TRIAZOL-1-YL)BUTYL)PHENYL)BENZO[D]THIAZOL-2-AMINE structure, CAS 201410-53-9](/structures/180000/161066_1_201410_53_9.png)
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 201410-53-9 |
| Catalog No. | 2A-0161066 |
| Chinese Name | n-[4-[2-乙基-1-(1H-1,2,4-噻唑-1-基)丁基]苯基]-2-苯并噻唑胺 |
| Synonyms | Talarozole |
| Molecular Formula | C21H23N5S |
| Molecular Weight | 377.51 |
| Purity | 96+ |
| Storage Condition | 2-8℃ |
| Application | Talarozole is a potent inhibitor of CYP26A1 and CYP26B1 with IC50 of 5.4 and 0.46 nM, respectively. |
| EINECS | 0 |
| HTC | 2934200090 |
| UN(IATA) | 0 |
| PubChem ID | 14755739 |
| MDL Number | C21H23N5S |
| SMILES | CCC(CC)C(c1ccc(Nc2nc3ccccc3s2)cc1)n1cncn1 |
| InChI | InChI=1S/C21H23N5S/c1-3-15(4-2)20(26-14-22-13-23-26)16-9-11-17(12-10-16)24-21-25-18-7-5-6-8-19(18)27-21/h5-15,20H,3-4H2,1-2H3,(H,24,25) |
| InChI Key | SNFYYXUGUBUECJ-UHFFFAOYSA-N |
| MSDS | msds/161066_1_201410_53_9.pdf |
| Use of | Talarozole is a potent inhibitor of both CYP26A1 and CYP26B1, with IC50s of 5.4 and 0.46 nM, respectively. Properties Name N-{4-[2-Ethyl-1-(1H-1,2,4-triazol-1-yl)butyl]phenyl}-1,3-benzothi azol-2-amine Synonym More Synonyms Talarozole Biological Activity Description Talarozole is a potent inhibitor of both CYP26A1 and CYP26B1, with IC50s of 5.4 and 0.46 nM, respectively. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Inflammation/Immunology References [2]. Topletz AR, et al. Induction of CYP26A1 by metabolites of retinoic acid: evidence that CYP26A1 is an important enzyme in theelimination of active retinoids. Mol Pharmacol. 2015;87(3):430-41. [3]. Faith Stevison, et al. CYP26 Inhibition Increases Retinoic Acid Concentrations in Target Tissues and Alters Retinoid Signaling [4]. Tripathy S, et al.All-Trans-Retinoic Acid Enhances Mitochondrial Function in Models of Human Liver. Mol Pharmacol. 2016 May;89(5):560-74. Chemical & Physical Properties Molecular Formula C21H23N5S Exact Mass 377.16700 PSA 83.87000 LogP 5.73000 InChIKey SNFYYXUGUBUECJ-UHFFFAOYSA-N Storage condition 2-8℃ Safety Information HS Code 2934200090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934200090. other compounds containing in the structure a benzothiazole ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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